FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND CHLORTHALIDONE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
A simple, precise, and accurate method was developed for the estimation of Telmisartan (TEL) and Chlorthalidone (CHL) in bulk and pharmaceutical dosage form using first order derivative spectrophotometry. Wavelength selected for quantitation were 264.85nm for Telmisartan (zero crossing point of Chlorthalidone) and 222.38nm for Chlorthalidone(zero crossing point of Telmisartan). The method was validated with respect to linearity, accuracy, precision, limit of detection and limit of quantitation in accordance with the International Conference on Harmonisation (ICH) guidelines. Linearity was observed in concentration range of 8-48 µg/ml for Telmisartan and 2.5-15 µg/ml for Chlorthalidone. The limit of detection and limit of quantitation were found to be 0.234µg/ml and 0.712 µg/ml for Telmisartan and 0.102 µg/ml and 0.309 µg/ml for Chlorthalidone. The percentage recovery of Telmisartan and Chlorthalidone was found to be 99.26% and 99.36% respectively. The % R.S.D. values for intra-day and inter-day precision study were <1.0%, confirming that the method was sufficiently precise. The method can be successfully employed for the simultaneous estimation of Telmisartan and Chlorthalidone in pharmaceutical formulations.
Authors and Affiliations
Kreny Parmar , R. S. Mehta
Keywords
Related Articles
- EP ID EP114854
- DOI 10.7897/2230-8407.04348
- Views 103
- Downloads 0
EVALUATION OF THE KNOWLEDGE OF PATIENTS, COMPLIANCE TO TREATMENT AND THE IMPACT OF PATIENT EDUCATION ON ASTHMA: A QUESTIONNAIRE BASED STUDY ON OUTPATIENT ASTHMATICS
The purpose of this study was to evaluate the patient knowledge of asthma, their compliance to treatment, providing patient education and evaluating the impact of education on asthma management. With this view an interve...
AN UPDATED OVERVIEW ON PEPPERMINT (MENTHA PIPERITA L.)
Mentha piperita L. (Family: Lamiaceae; Synonym: M. balsamea Wild; commonly known as peppermint) is a natural hybrid (M. aquatica × M. spicata) with immense therapeutic uses (oldest known medicinal plant species, “medicin...
ASSESSMENT OF ANALGESIC, ANTIDIARRHOEAL AND CYTOTOXIC ACTIVITY OF ETHANOLIC EXTRACT OF THE WHOLE PLANT OF BACOPA MONNIERI LINN
The ethanol extract of the whole plant of Bacopa monnieri Linn. (Scrophulariaceae) was investigated for its possible analgesic, antidiarrhoeal and cytotoxic activities in animal models. The extract produced significant w...
MEDICINAL PLANTS WITH POTENTIAL ANTICANCER ACTIVITIES: A REVIEW
Plants have been the beacon of therapeutic sources for curing diseases from times immemorial. Medicinal plants with their isolated lead molecules are also used as an alternative medicine for treating neoplastic cells. Ne...
ANTIMICROBIAL ACTIVITY OF BIOSYNTHESIZED SILVER NANOPARTICLES PREPARED FROM THE LEAF EXTRACT OF LANTANA CAMARA
Lantana camara commonly known as weed or red sage is found throughout India. It was reported to be used in traditional medicine system for infectious diseases. The present study designed to evaluate antimicrobial activit...