Fishing for the Hidden Peptidome in Health and Disease (Drug Abuse)
Journal Title: The AAPS Journal - Year 2010, Vol 12, Issue 4
Abstract
The proteome and peptidome are defined as the set of proteins and peptides present in a tissue or other biological sample. In most proteomic studies, only abundant proteins are detected and, although these are important molecules, they are often well-studied structural proteins. A number of approaches have been used to examine less abundant molecules that play roles in signaling or otherwise have regulatory functions, including peptides as well as proteins such as enzymes and receptors. The overarching goals of this special issue involve defining the peptidome, identifying the current state of the field, and discussing methods to characterize the peptides, their receptors, and future needs for such measurements.
Authors and Affiliations
Lloyd D. Fricker, Jonathan V. Sweedler
Keywords
Related Articles
- EP ID EP681412
- DOI 10.1208/s12248-010-9228-7
- Views 54
- Downloads 0
Bayesian Quantitative Disease–Drug–Trial Models for Parkinson’s Disease to Guide Early Drug Development
The problem we have faced in drug development is in its efficiency. Almost a half of registration trials are reported to fail mainly because pharmaceutical companies employ one-size-fits-all development strategies. Our o...
Successes Achieved and Challenges Ahead in Translating Biomarkers into Clinical Applications
Biomarkers are important tools for identifying and stratifying diseases, predicting their progression and determining the effectiveness, safety, and doses of therapeutic interventions. This is important for common chroni...
CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48
The online version of this article (doi:10.1208/s12248-015-9788-7) contains supplementary material, which is available to authorized users.
Utility of a Bayesian Mathematical Model to Predict the Impact of Immunogenicity on Pharmacokinetics of Therapeutic Proteins
The impact of an anti-drug antibody (ADA) response on pharmacokinetic (PK) of a therapeutic protein (TP) requires an in-depth understanding of both PK parameters and ADA characteristics. The ADA and PK bioanalytical assa...
A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data
The aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix tablets. For this purpose, two differen...