Five-Years Tigecycline Experience an Analysis of Real-Life Data
Journal Title: HASEKİ TIP BÜLTENİ - Year 2018, Vol 56, Issue 2
Abstract
Aim: Tigecycline has been approved by the Food and Drug Administration for the treatment of complicated intra-abdominal infections, skin and soft tissue infections and community-acquired pneumonia. In our study, we examined the efficacy of tigecycline in clinical practice and reported real life data from our hospital over a period of five years. Methods: The study was conducted between 2008 and 2013 on patients who received tigecycline for longer than 48 hours in Ankara Training and Research Hospital. Clinical success was defined as clinical recovery and microbiological cure in patients who used tigecycline. Any reason for discontinuation of tigecycline treatment was considered a clinical failure. Results: In our hospital, 320 patients were administered tigecycline between 2008 and 2013. Tigecycline was mainly used for pneumonia and skin and soft tissue infections. Tigecycline was used as monotherapy in 174 patients (54.1%). The most frequently isolated agent in tigecycline-treated patients was Acinetobacter baumannii (43.4%) followed by Enterococcus (6.9%). A change in treatment was not considered necessary in 243 (75.9%) patients who received tigecycline, while it was changed in 77 patients (24.1%). Conclusion: In conclusion, the use of tigecycline can be an effective treatment choice, either as monotherapy or as a combination antibiotic therapy.
Authors and Affiliations
Fatih Temocin, Necla Eren Tülek, Şirin Hekimoğlu, Tuba Ilgar, Cemal Bulut, Fatma Şebnem Erdinç, Günay Tuncer Ertem, Çiğdem Ataman Hatipoğlu, Sami Kınıklı
Keywords
Related Articles
- EP ID EP368718
- DOI 10.4274/haseki.42713
- Views 111
- Downloads 0
Multiseptate Gallbladder, a Rare Cause of Recurrent Abdominal Pain: A Case Report and Review of the Literature
Multiseptate gallbladder is a rare congenital malformation. It was first described by Simon and Tandon in 1963. A 1-year-old boy was admitted to our clinic with the complaints of intermittent abdominal pain and itching....
Flow-Mediated Dilatation and Asymmetric Dimethylarginine Do Not Predict Mortality in Peritoneal Dialysis Patients
Aim: Asymmetric dimethylarginine (ADMA) is associated with increased coronary artery disease risk through endothelial dysfunction in dialysis patients. We aimed to investigate the role of flow-mediated dilatation (FMD),...
Investigation of ErbB and Insulin Signaling Pathways in the Pathogenesis of Multiple Myeloma
Aim: Analysis of genes that play roles in multiple myeloma pathogenesis and their pathways are current research topics. We aimed to detect expression of some genes in ErbB and insulin signaling pathways. Methods: Bone m...
The Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clone in Adult Patients with Idiopathic Pulmonary Hypertension
Aim: Paroxysmal nocturnal hemoglobinuria (PNH) a is a clonal disorder that may lead to several conditions such as thromboses, Budd-Chiari syndrome, renal failure, impotence, and pulmonary hypertension (pHT). Since the pr...
Mount Fuji Sign: A Rare Complication of Meningitis
Acute bacterial meningitis is a critical condition also because of associated complications and sequelae besides being a life-threatening infection. The complications may develop due to disease itself, diagnostic procedu...