FLAVONOID-RICH EXTRACT OF SOLANUM MACROCARPON LEAVES SHOWS TISSUE PROTECTIVE AND AMELIORATE CERTAIN INFLAMMATORY AND OXIDATIVE INDICES ASSOCIATED WITH D-GALACTOSE EXPOSED RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 2
Abstract
present study assessed the protective potentials of Flavonoid-Rich Extract of Solanum macrocarpon Leaves (FRESML) against D-galactose-induced oxidative stress in rats. Animals were randomly selected into four groups of seven per group and treated for 28 days. Group A (control) were given distilled water, Group B (extract only) were administered 100mg/kg/day of FRESML, Group C (D-galactose only) were administered 500mg/kg/day of D-galactose and Group D (D-galactose + extract) received combined administration of 500mg/kg/day of D-galactose and 100mg/kg/day of FRESML. Total Protein (TP), Urea and Creatinine concentrations, Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Gamma Glutamyl Transaminase (GGT), Superoxide Dismutase (SOD) and Catalase activities, Reduced Glutathione (GSH), Malondialdehyde (MDA), Packed Cell Volume (PCV), White Blood Cell (WBC) and Fibrinogen levels were assessed using standard assay methods. D-galactose administration in rats triggered significant (p<0.05) increases in serum levels of ALT, AST, GGT, ALP, Urea and Creatinine and significant (p<0.05) decreases in serum, liver and kidney TP concentrations. Significant (p<0.05) increases in percentage PCV, WBC counts and Fibrinogen concentration were obtained. In addition, significant (p<0.05) increases in liver and kidney MDA concentrations and depletion in liver and kidney SOD, Catalase and GSH levels were also obtained. Combined administration of D-galactose and FRESML significantly (p<0.05) modulated the levels of ALT, AST, GGT, ALP, Urea and Creatinine and significantly (p<0.05) increased serum, liver and kidney TP to nearly control levels. The extract significantly (p<0.05) reversed D-galactose-induced increases in percentage PCV, WBC counts, Fibrinogen and MDA concentration and increases liver and kidney SOD, Catalase and GSH to nearly control level. Group treated with the extract alone showed no adverse effects on the parameters. Results are possible indication of FRESML ability to protect against cellular oxidative stress in tissues, boost antioxidant status and ameliorate inflammation associated with oxidative stress.
Authors and Affiliations
Seyi Elijah Elasoru
Keywords
Related Articles
- EP ID EP621219
- DOI -
- Views 135
- Downloads 0
UNDERSTANDING OF YONI ARSAS IN AYURVEDIC CLASSICS
Though the term arsh in common parlance means, only ano-rectal disorder, the mention of similar condition occurring elsewhere in the body like karna, nasa, medhra or yoni etc do attract the attention of modern scholars....
3D QSAR STUDIES OF BENZIMIDAZOLE DERIVATIVES AS FtsZ INHIBITORS
Tuberculosis is one of the most infectious disease in the world. Filamentous Temperature Sensitive Mutant Z gene (FtsZ) being a strong target implies an efficacious therapy for tuberculosis treatment. Amongst the entire...
SOLID WASTE MANAGEMENT: A CHALLENGE TO OUR SOCIETYCASE STUDY JHANSI, UTTAR PRADESH
The waste has potential to pose threat to land air and soil. The poor solid waste management leads to social, economic, health and environmental problems. Jhansi is famous for being tourist city of the UP state. The prob...
POST-TREATMENT AUGMENTATION OF ANGIOGENESIS AND ANTI-OXIDATIVE INDEX OF ADULT STEM CELLS DERIVED FROM WHARTON’S JELLY
Objectives: The umbilical cord is proven as a potential source of adult stem cells, due to its abundance, harvesting, deficiency of ethical issues and wider potential of differentiation. Mesenchymal stromal cells (MSCs)...
A STUDY TO EXAMINE THE FORENSIC TOXICITY OF RICIN
Ricin is a protein-based toxin that comes from the castor bean plant (Ricinus communis) alongside another protein called the Ricinus communis agglutinin (RCA120). These two proteins are dangerous to human health. Liquid...