Fluctuation in the Levels of Immunoglobulin M and Immunoglobulin G Antibodies for Cardiolipin and β2-Glycoprotein among Healthy Pregnant Women
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 4
Abstract
Objectives: Antiphospholipid antibodies fluctuate during a healthy normal pregnancy. Tis study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzymelinked immunosorbent assay. Results: Te ACA IgM levels were signifcantly higher in the control group compared to the pregnant women (P <0.001). No signifcant differences were observed in the ACA IgM levels between the control group and the pregnant women after delivery. In contrast, ACA IgG levels were signifcantly higher during pregnancy and after delivery compared with those of the healthy control group (P = 0.007 and 0.002, respectively). Te levels of β2GP IgG were signifcantly higher during pregnancy than after delivery and in the control group (P = 0.001 and <0.001, respectively). Conclusion: In this study, ACA IgG levels increased during healthy pregnancies and after normal deliveries whereas β2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be signifcantly associated with a transient decline in the levels of IgM specifc for these antigens. Terefore, the levels of these antibodies may be regulated during a healthy pregnancy.
Authors and Affiliations
Mohammed S. Al-Balushi| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman& These authors contributed equally to this work, Sidgi S. Hasson| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman& These authors contributed equally to this work, Elias A. Said| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman& These authors contributed equally to this work, Juma Z. Al-Busaidi| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Muna S. Al-Daihani| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Mohammed S. Othman| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Talal A. Sallam| Department of Community Health, Al Baha University, Al Baha, Saudi Arabia, Mohammed A. Idris| Departments of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Moza Al-Kalbani| Departments of Obstetrics & Gynaecology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Nicholas Woodhouse| Departments of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Ali A. Al-Jabri| Departments of Microbiology & Immunology, Sultan Qaboos University, Muscat, Oman
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