Flux Balance Analysis Based Model for the Identification of Potent Drug Target: A Novel Strategy
Journal Title: STAR Journal - Year 2013, Vol 2, Issue 1
Abstract
The work aims at developing a strategy for the identification of potent drug target by analyzing signaling pathways. The strategy developed is designed and tested in concern with Toll Like Receptor-4 (TLR4) signalling pathway. TLR4 pathway is a major pathway which get trigger against Lipo-polysaccheride (LPS) stimulus. The work describes a strategy to identify potent drug targets by understanding the flow of information in signaling pathways by representing them in the form of stoichiometric matrices and analyzing mathematically by adopting relatively successful approaches, including flux balance analysis (FBA), Single Value Decomposition (SVD). The strategy successfully proposes TNF-α Receptor Associated Factor-6 (TRAF6) as a potent drug target for LPS neutralization.
Authors and Affiliations
Bharath BR| Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, Karnataka, India, Manjunatha H| Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, Karnataka, India
Keywords
Related Articles
- EP ID EP9506
- DOI http://dx.doi.org/10.4314%2Fstar.v2i1.98844
- Views 386
- Downloads 18
Evaluation of Antimicrobial Activity of Some Traditional Medicinal Plants and Herbs from Nekemte District against Wound Causing Bacterial Pathogens
No Abstract
Modeling and Performance Analysis of Manufacturing Systems in Footwear Industry
This study deals with modeling and performance analysis of footwear manufacturing using arena simulation modeling software. It was investigated that modeling and simulation is a potential tool for modeling and analysis...
Biosorption of Hexavalent Chromium Using Bark of Cassia spectabilis
Biosorption is a relatively new process that has proven very promising in the removal of heavy metal contaminants from aqueous solutions. The biosorption of Cr(VI) from aqueous solution using bark of Cassia spectabilis...
Citrus Production, Constraints and Management Practices in Ethiopia: The Case of Pseudocercospora Leaf and Fruit Spot Disease
Citrus is economically important fruit crop in Ethiopia. However, its production is seriously constrained by various diseases including Pseudocercospora leaf and fruit spot. Surveys were conducted between June 2012 and...
First Report of Fusarium proliferatum Causing Rot of Onion Bulbs (Allium cepa L.) in India
A rot disease was observed on onion bulbs in major growing areas of Kadapa and Kurnool districts of Andhra Pradesh, India during 2010 to 2012. Based on pathogenicity, morphology and ribosomal DNA spacer sequences, the...