Follicular Dendritic Cells Sarcoma in Accessory Salivary Glands
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 2
Abstract
Follicular Dendritic cells sarcomais a relatively rare entity with intermediate malignancy. Their evolution is characterized by the frequency of local and/or remote relapses. Due to their rarity, the treatment is not consensual in the literature. We report a rare case of follicular dendritic cells sarcoma of accessory salivary glands in a 45-year-old patient whose progression is favorable after surgery followed by chemo-radiotherapy and review of the literature. Follicular Dendritic cellstumors are rare entities (less than 1% of malignant salivary gland tumors). Only a few cases have been reported in the literature [1-2]. In addition to their rarity, these tumors shows difficulties in the diagnosis of certainty and in the optimal the rape utic strategy. We report an exceptional case of follicular dendritic cell sarcoma of submaxillary accessory salivary glands in a 45-year-old man and discuss the therapeutic strategy based on data from the literature. Observation: A 45-year-old patient with no previous medical history who consulted for a right latero-cervical swelling, increasing gradually in volume for 3 months, with no pain or other associated otolaryngologic signs. The cervical ultrasound showed a vascularized lesion under the right angulo-mandibular measured 6.5 cm of major axis. The cervical CT scan showed a right sub-angulomandibular tumoallesion develop that the expense of an accessory salivary gland of the inner surface of the lowerlip, mesured 65 x 33mm, with no significant cervical adenopathy or involvement of the parotid glands, Submaxillary or thyroid (Figure 1). The patient had a biopsy excision of the mass. In the macroscopic study, it was an encapsulated mass mesured 7 cm of long axis, of whitish aspect quite homogeneous. Histologically, tumorous proliferation of diffuse architecture was described containing void cells with invisible cytoplasmic boundaries (Figure 2). Exercise margins were healthy at 1 cm. The mitotic index was high (19 mitoses / 10 fields at high magnification), with the presence of some three-pole mitoses. The immuno-histochemical profile was consistent with a follicular dendritic cells sarcoma in full resection, confirmed by the presence of the anti-CD23 antibody (clone MHM6, DAKO, CAPA) But negativity of anti-CD45 antibodies, anticytokératine, and PS100 (Figure 3). Postoperative extension assessement by cervicothoraco- abdomino-pelvic scan was normal. Discussion Follicular dendriti cells (CDFs) are part of the accessory cells of the lymphoid system whose main functionis the presentation of Follicular dendriti cells (CDFs) are part of the accessory cells of the lymphoid system whose main functionis the presentation of the lympho-follicular B antigen. Originally described by Monda et al. In 1986, folliculardendritic cellss arcomare present a rare entity, Belonging, according to the 2008 classification of the World Health Organization (WHO) to the group of tumors with histiocytic and dendritic cells [1]. On the epidemiological level, there appears to be a slight male predominance with a median age of 40 years (9 to 86 years) [2-3]. Castleman’s disease of vascular or plasma hyaline form is found in 10 to 20% of cases [4]. The lymph node involvement is present in 50 to 66% of cases, especially at the cervical level. The most common site of this type of tumoris at the Head and Neck level (mainly palatal tonsils), followed by other localizations (spleen, digestive tract, liver, soft tissue, skin). Macroscopically, follicular dendritic cell sarcoma is generally well-defined, of solid consistency, greyish in color, with in some cases foci of necrosis and haemorrhage [5]. Microscopically, tumor proliferation consists of fusiform, polygonal or ovoid cells of varying architecture (storiform, fascicular, in sheet or nodule, sometimes with windings). The nucleus iselongated, with vesicular chromatin or finely granular and containing a some times prominent nucleolus. The mitotic index is variable from 0 to 10 mitoses / ten fields [2-6]. Our patient had a very high mitotic index at 19 mitoses / 10 fields. On the immuno histochemical (IHC) level, the tumorcells express at least one of the markers of the dendritic follicular cells (CD23, CD35, CD21, CNA42). There was also a positivity for vimentin, EMA in 40-45%% of cases, PS100 in 30-35% of cases and CD68. There is no immuno reactivity for epithelial markers (cytokeratine) and HMB45 [7-8]. In our case, the IHC study showed a positivity of the anti-CD 23. The main differential diagnosis of follicular dendritic cells sarcoma is the metastases of an undifferentiated carcinoma or an achromic melanoma. However, the absence of expression of cytokeratin AE1-AE3, HMB45 and Melan A by tumor cells makes it possible to eliminate these diagnoses. Another differential diagnosisis interdigital cells sarcoma with clinical and morphological presentation comparable with follicular dendritic cells sarcoma, but it distinguished by the absence of follicular dendritic cells markers expression. The immuno histo chemical study present a major interest for the diagnosis [6-8]. The mixed phenotype of these sarcomas and their incompletely elucidate devolution make the treatment options difficult to define. The sarcomatous phenotype would rather advocate a therapeutic attitude including radical surgery followed by adjuvant radiotherapy whereas the follicular lymphomatous phenotype would rather advocate for isolated radio therapy in stage I or a combination of chemotherapy and local radiotherapy [7,8]. Surgery is the dual, diagnostic and therapeutic reference treatment [3]. There is no specific modality for surgery given the rarity of this type of tumor. Thus, the sarcomatoid phenotype to encourage broad local surgery with sufficient healthy margins. Lymph ademectomy is recommended only in case of macroscopic involved nodes, given the low lympho philicpotential estimate 10% [5]. In the Perkins and Shinohara series, the most important of the literature, there was no evidence to support chemotherapy [3].
Authors and Affiliations
Youbi Zakaria Ahmed, Hassan Jouhadi, Leila Benfaress, Benider Abdelattif, Yossi Sena
Keywords
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- EP ID EP569249
- DOI 10.26717/BJSTR.2017.01.000231
- Views 144
- Downloads 0
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