FORMULATING FAST DISINTEGRATING ZINC TABLET USING SINGLE STRUERS LABOPRESS-1
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 4
Abstract
The purpose of our research work was to formulate tablets of zinc as a nutritious element by direct compression method employing different disintegrants and ascorbic acid as an antioxidant at different proportions in addition to other excipients used in tablet formulation, in order to enhance the disintegration/dissolution rate as well as the percentage drug release. Pre-compression parameters which include bulk and tapped densities, Carr’s index, Hausner’s ratio were evaluated and found to be within acceptable limits. Weight variation, hardness, friability, disintegration time, and in vitro dissolution profile of the formulated tablets were evaluated. Following the data obtained from the dissolution study carried out in 900ml phosphate buffer of 0.05M, 6.8 pH at 37±1˚C, the best batch was found to formulations in batch I; because the formulations in this batch I were able to release 99.8% of the drug within 10 minutes. Furthermore, the data obtained were analyzed and found to be significantly difference at p<0.05.
Authors and Affiliations
Okey-Mbata Chioma Chinyere
Keywords
Related Articles
- EP ID EP649058
- DOI -
- Views 171
- Downloads 0
NASYA KARMA IN NETRA ROGAS
The importance of eye was underscored in ayurveda by quoting eye as the most important of all sense organs: “Sarvendriyanam madhye nayanasya pradhanatvath”- eyes hold special status among all the sense organs.Nasya karma...
ANTIBACTERIAL ACTIVITY OF ACHYRANTHES ASPERA L.
The Plants are known for their diverse pharmacological activities including antimicrobial activity. Plant products work as a substitute to synthetic products because of easy availability. In the present work an attempt h...
BIOPSY- AN OVERVIEW
Proper management of an oral mucosal lesion begins with diagnosis, and the gold standard for diagnosing disease, oral or otherwise, is tissue biopsy. Oral tissue biopsy may be necessary for lesions that cannot be diagnos...
AT RISK NEWBORN: THE NEED FOR LIFE-SAVING CARE
Some newborns are delivered before the attainment of healthy weight and full development in various vital organs. This places such newborn in dire need of critical life-saving care that can be accessed in the neonatal in...
EFFECTIVENESS OF SHIRODHARA IN HYPOTHYROIDISM: A NARRATIVE REVIEW
Background:-Thyroid diseases are possibly, among the commonest endocrine disorder worldwide. India too has a significant burden of thyroid diseases. Several studies had been carried out till date emphasizing the role of...