FORMULATION AND CHARACTERIZATION OF FLOATING MICROSPHERES OF ACARBOSE BY SOLVENT EVAPORATION METHOD
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 4
Abstract
Objective: The purpose of the present investigation was the formulation and characterization of Gastro-retentive floating microspheres of anti-diabetic drug Acarbose that would retain in the stomach and continuously release to improve bioavailability.Methods: There were various formulations of acarbose were prepared by solvent evaporation technique using hydroxy propyl methylcellulose (HPMC) and Ethyl cellulose (EC) as a polymer and they were evaluated for particle size, surface morphology, drug entrapment efficiency, flow properties, buoyancy percentage and In-vitro drug release and stability studies.Result: The shape and surface morphology of prepared floating microspheres were characterized by optical and scanning electron microscopy, respectively. The particle was found to be discrete and spherical with the average particle size in the range of 105.54 to 413.5 micrometer. As the concentration of polymers increases, it affects the various evaluation parameters like particle size, in-vitro drug release, and buoyancy. The floating microspheres of optimized formulation exhibited the prolonged release of 89.9% in a constant way up to 12 hours and remain buoyant more than 12 hours. Conclusion: From this study It is concluded that the optimized formulation of Acarbose floating microspheres can be selected for gastro retentive drug delivery system for improved bioavailability and gastric residence time.
Authors and Affiliations
MANISH KUMAR SHARMA
Keywords
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