Formulation and Characterization of Self Emulsifying Drug Delivery System of Simvastatin Using Maringa Oleifera and Banished Oil Extract For Potential Pharmaceutical Application
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 5
Abstract
Poor aqueous solubility of some chemical entities presents a major challenge to modern drug delivery. Self emulsifying drug delivery systems (SEDDS) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SEDDS are mixtures of oil, surfactant and co-surfactant which are emulsified in aqueous media under conditions of mild agitation and digestive motility that are encountered in the gastrointestinal (GI) tract. The aim of this study was to develop a novel formulation of SEDDs using simvastatin which is a poorly water soluble drug. The study was conducted by preparing SEDDS with moringa oleifera and beniseed oils, tween 80 (surfactant) and polyethylene glycol (co-surfactant). After screening of various vehicles (oil, surfactant and co-surfactant) based on better drug solubilising power, liquid SEDDS were formulated. Prepared formulation were characterized on the basis of self emulsification ability, emulsification time, phase separation, spontaneity of formation, viscosity. A total of 8 samples were prepared comprising samples F1-F8 (tween 80, BSO, MSO and PEG-200). F1-F3 formed clear transparent and stable mixtures and were selected for further studies. The formulations that showed otherwise were rejected. Prepared SEDDS with simvastatin were made to undergo thermal stability tests which comprise heating cooling cycle, centrifugation test and freeze thawing test and were all found to be stable at different temperature conditions. Percentage drug content showed good result as most of the formulations showed good drug content of 70% and above. IR spectra of the formulations also showed good drug absorption and no drug interaction with the formulation. Cloud point determination of the formulation showed that the formulations were stable at physiological temperature. This study shows that the formulation will help to overcome the problem of poor solubility, bioavailability and fast drug release and therefore can be suitable for oral delivery systems.
Authors and Affiliations
Onyirioha N. N, Barminas J, Osemeahon S
Keywords
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- EP ID EP414049
- DOI 10.9790/5736-1105013642.
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