Formulation and Characterization of Sustained Release Matrix Tablets of Indomethacin Using Moringa Oleifera Gum
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Solid dispersion techniques have been used during the past few decades to increase solubility and bioavailability of poorly soluble drugs. In recent years in addition to solubility and bioavailability enhancement more attention has been paid to use solid dispersion techniques for the development of sustained release dosage forms. The solid dispersion techniques have a great potential in the area of sustained release dosage form design because of availability of wide variety of carriers. Hydrophilic natural polymers are widely used in the formulation of oral dosage forms. Their ability to hydrate and form a gel layer are well known and essential to retard the drug release from the formulation. Hence the work was planned for selection, extraction and purification of natural gum Moringa oleifera. Indomethacin solid dispersions were prepared by using PEG 8000 as a carrier by employing solvent evaporation method and melting method. Further matrix tablets were prepared with 5%, 10%, 15% of natural polymer like Moringa oleifera, synthetic and semi synthetic polymers like HPMC K15 and Eudragit RL100. Tablets prepared were evaluated for the release of indomethacin over a period of 12 h in pH 7.2 phosphate buffer using US Pharmacopoeia type II dissolution apparatus. The in vitro drug release study revealed that the tablet containing Moringa oleifera gum has extended the release rate for 12 h whereas the tablet containing HPMC K15 and Eudragit RL100 at the same concentrations was not extended the release rate up to 12 h.
Authors and Affiliations
S. V. Vijaya Lakshmi1, R. P . Swain2
Keywords
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