FORMULATION AND DEVELOPMENT OF ENALAPRIL MALEATE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD AND ITS PHARMACEUTICAL EVALUATION
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2019, Vol 5, Issue 1
Abstract
In the project work Enalapril maleate, an anti hypertensive drugs has been formulated into fast dissolving tablets by direct compression method using the different super disintegrates such as croscarmellose and sodium starch glycolate and Excipients like lactose, sucrose magnesium stearate, sodium lauryl sulphate the prepared by the tablets were evaluated for the pre-compression parameter UV Spectroscopy, post compression parameter such as thickness, hardness, friability, drugs contents, weight variation, water absorbance ratio, invitro disintegrating time, invitro dissolution studies. No chemical interaction between drugs and Excipients was conforming by FTIR study. All the parameter shows good results. Fast dissolving tablets are prepared by direct compression method are results found to be that among of nine formulation as the F9 to be best as its shows in F9 87.10% (direct compression method) maximum drug release respectively. The prepared tablets stability tested at 400c having 75% relativity humidity for 1month and found to be stable. Prepared fast dissolving tablets of Enalapril maleate 5 mg was found to be under fasting fed condition.
Authors and Affiliations
Shama Parveen
Keywords
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