FORMULATION AND DEVELOPMENT OF IN SITU FORMING GEL FOR THE TREATMENT OF ORAL THRUSH
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8
Abstract
Objective: The objective of the present work was to develop an in situ gel composed of Pluronic F-127, Carbopol 934, and methylparaben and loaded with fluconazole using DoE software to sustain the delivery of drug in the buccal cavity.Methods: In situ gels were prepared by temperature-induced method, by employing DoE and characterized by Fourier transform infrared (FTIR), differential scanning calorimeter (DSC), and evaluated for gelation temperature, gelation time, adhesive force, and in vitro diffusion studies.Results: Both FTIR and DSC studies suggested that there were no chemical interactions present between both drug and polymers. The formulated gels S1, S3, and S9 showed gelation at a body temperature. The viscosity, gel strength, and mucoadhesive force for the formulated in situ gels were found to be within the ranges of 375–738 cps, 35–62 s, and 4650–5210.32 dynes/cm2, respectively. The in vitro diffusion studies indicated that optimized in situ gel S3 exhibited the improved ability to sustain the drug compared to other formulations.Conclusion: Thus, developed in situ gel system was determined to be effective in terms of eradication of oral thrush.
Authors and Affiliations
Akshay Kumar S, Vishal Gupta N, Gowda Dv, Praveen Sivadasu
Keywords
Related Articles
- EP ID EP567363
- DOI 10.22159/ajpcr.2018.v11i8.26190
- Views 135
- Downloads 0
QUALITY CONTROL EVALUATION OF IN HOUSE PREPARED POLYHERBAL AYURVEDIC FORMULATION SAPTAVIMSATIKA GUGGLU
Introduction: Plants and their constituent are having potential of treating any human suffering in form of disease. Various combination of plant extract is used as a remedy for treating these disorders. However the usage...
REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF EMTRICITABINE, RILPIVIRINE, AND TENOFOVIR ALAFENAMIDE IN SOLID DOSAGE FORM
Objective: A stability indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of emtricitabine (EMT), rilpivirine (RIL), and tenofovir alafenamide...
EVALUATION OF ANTIBACTERIAL ACTIVITY OF INDONESIAN VARIETIES SWEET POTATO LEAVES EXTRACT FROM CILEMBU AGAINST Shigella dysenteriae ATCC 13313
Objective: The aim of this study was to evaluate the in Vitro antibacterial  activity of sweet potato (Ipomoea batatas (L.) Lam) leaves ethanol extract  against Shigella dysenteriae ATCC 13313.Methods: The study was pe...
ISOLATION, SCREENING AND CHARACTERIZATION OF POTENT MARINE STREPTOMYCES SP. PM 105 AGAINST ANTIBIOTIC RESISTANT PATHOGENS
 Objectives: The present study aims to screen and isolate a promising strain of actinobacteria for the development of new antibiotic to fight againstlife-threatening infectious diseases.Methods: A total of 59 marine sam...
EVALUATION OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF DIPLOCYCLOS PALMATUS FRUITS ON ALBINO MICE
Objective: The present study is preplanned to assess the antimicrobial and analgesic activity of the collected plants of Diplocyclos palmatus from Moinabad, Ranga Reddy, Telangana. Methods: In this study, D. palmatus fr...