FORMULATION AND DEVELOPMENT OF KETOROLAC TROMETHAMINE OPHTHALMIC SOLUTION
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 3
Abstract
An acetic acid derivative ketorolac tromethmine has found its applicability in both gram positive and gram negative bacterial ocular infection and used commonly associated with multiple doses. Ophthalmic medication stored in multiple dose containers is required by the U.S. Food and Drug Administration to contain a preservative so that patients are provided with microbe free medication. Benzalkonium chloride in concentrations from 0.1% to 0.0001% induced dose-dependent growth arrest and conjunctiva epithelial cell death, either delayed or immediately after administration. In such case, a preservative Benzalkonium chloride must be used within reasonable bound. Benzalkonium chloride can provide more help than harm. Hence the present study focusing on to formulate a formulation for ketorolac tromethmine (0.5%) ophthalmic solution using different concentration of Benzalkonium chloride as preservative.
WATER ABSORPTION, XRD AND FTIR ANALYSIS OF PBS-STARCH BLENDED HALLOYSITE COMPOSITES
Poly (butylene succinct) (PBS)/starch/halloysite nanotubes(HNT) composite was fabricated through solution casting using deionised water. The effect of HNT on the water absorption behavior of the composites has been studi...
DEPRESSION AND ITS PHARMACOLOGICAL MANAGEMENT: A CRITICAL REVIEW
Depression is considered as an affective disorder characterized primarily by change of mood. It is associated with significant socioeconomic problems, morbidity and mortality. The prevalence of major depression in the ge...
EVALUATION OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY OF SEEDS USED IN TRADITIONAL MEDICINE
Phytochemicals are secondary metabolites of plants which are non-nutritive chemicals that have protective or disease preventive properties. It is well known that plants produce these metabolites to protect itself but rec...
Study to assess the health issues among employees working in selected call centres of Mangalore
Background: The new mantra for job opportunities among young population is “call center”. Though Bangalore is considered as hub for call centres, the slowly call centres are emerging in Mangalore. Since this job has got...
Perspectives of Neer-Nirakkuri (colour of the urine) and diagnosis according to Saint Therar
The bioactive compounds and pH of the urine are the reason for dip and spike of its surface appearance. The colour variations relate on its primary and secondary metabolites due to the presence of bacterial reaction. The...