Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2020, Vol 5, Issue 1
Abstract
Quick slow drug delivery system involves the use of compressed core, consisting of sustained release tablet, which is coated by compression over the whole surface with fast dispersible formulation. Propranolol hydrochloride, a non selective beta adrenergic blocker has widely used in the treatment of hypertension and angina pectoris with frequent administration. Aim of present study was to develop press coated tablet system to achieve quick slow release of the drug are the main purposes of biphasic drug delivery system to avoid frequent administration with increasing patient compliance and therapeutic efficacy. In this study immediate layer which was prepared using croscarmellose sodium, crospovidone and sodium starch glycol ate which was compressed on core tablet prepared by using HPMC and Ethyl cellulose. Results showed that the immediate layer dissolved within four minutes and core tablet releases drug for 12 hrs in controlled manner with zero order release kinetics. Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza "Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd38190.pdf Paper URL : https://www.ijtsrd.com/pharmacy/other/38190/formulation-and-development-of-modified-release-biphasic-compressed-tablet-of-propranolol-hydrochloride/mrs-poonam-jaykar-patil
Authors and Affiliations
Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza
Keywords
Related Articles
- EP ID EP692391
- DOI -
- Views 86
- Downloads 0
Experimental Investigation of Strength Comparison of Various Percentages of Sawdust Added Clay Bricks
Now days the use of clay bricks in building construction is widely used. Such a time clay bricks to be used in better option of building construction as examining compared to the conventional clay bricks which is made by...
A Conceptual Review on the Study and Importance of Work Life Balance
The work life balance is having a significant role in organization and the eminence relationship between waged work and unpaid accountabilities is serious for achievement in today’s competitive professional world. Also,...
Problems and Challenges of Edible Oil Mill Workers: A Sociological Study in Challakere Talukin Chitradurga District
India is developing country in the world. Since Independence the government of India has undertaken several measures for industrial development. Industries are the back bone of every nation, India is not exception these,...
Job Satisfaction of Employees in Bharat Heavy Electricals Limited (BHEL), Tiruchirappalli
The Bharat Heavy Electricals Limited is one of the major industries for country's economic development. The main aim of this study is to assess the factors which are responsible for employee's job satisfaction. This pape...
Impact of Goods and Services Tax on Indian Economy
The Goods and Services Tax, also known as GST Goods and Service Tax , came into force in India on 01 July 2017. Now there is a free flow of goods in the country and the concern of tax rates of businessmen have ended. The...