Formulation and development of orodispersible tablets of lornoxicam by using resinate inclusion complexes
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2017, Vol 5, Issue 2
Abstract
Lornoxicam is a non-steroidal anti-inflammatory drug and it belongs to the class of oxicam. It is used for potent inhibitor of both COX-1 and COX-2. But it is a very bitter drug and insoluble in water. Aim: To mask the taste and to formulate into or dispersible tablet by complexation with ion exchange resins. Since, these tablets can be swallowed in the form of dispersion; they form a suitable dosage form for pediatric and geriatric patients. Method: A cation exchange resin like Kyron T- 134 was utilized for the complexation with drug. Drug-resinates was prepared in drug to resin ratio of 1:3.75. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, taste evaluation, mouth feel, wetting time, disintegration time, and in-vitro dissolution studies. Result: Tablets with these resins have shown quick disintegrating features, i.e., within 20 seconds, which is very characteristic of orodispersible tablets. The dispersion not showing any bitter taste, indicate the capability of ion exchange resins used, both as taste masking and super disintegrating agents. Almost more than 90% of drug was released from both the formulations with in 1 hour. Further formulations were subjected to stability testing for three month at temperature at 40°C/ 75% RH
Authors and Affiliations
Tanvir J. Shaikh
Keywords
Related Articles
- EP ID EP570107
- DOI -
- Views 103
- Downloads 0
Clinical Trials Registry- India (CTRI)
The Clinical Trials Registry- India (CTRI), hosted at the ICMR’s National Institute of Medical Statistics (NIMS), is an online public record system for registration of clinical trials being conducted in India. The CTRI (...
Advanced injectable drug delivery system: A brief review
In modern therapeutics the controlled/sustained release dosage forms have become extremely popular. Development of sustained release injectable has occurred in the past few years. This was brought into existence to prolo...
Mycobacterium tuberculosis has affinity of frequent mutation in the codon sequence 530-533 of mutation type serine 531 leucine
As long as MDR-TB verified, use of inadequate and hence ineffective antibiotics may lead to further spread of resistant bacteria and amplification of resistance. Therefore, rapid diagnosis and identification of MDR-TB is...
The effectiveness of foot massage on relief of the foot pain among staff nurses working in emergency unit
Foot pain is the most common health problem among staff nurses working in the emergency units. An experimental study was conducted to assess the effectiveness of foot massage on relief of foot pain among staff nurses wor...
Hepatoprotective activity of ethanolic extract of Euphorbia royleana linn in carbon tetrachloride treated guinea pig
The present study has been designed to explore and provide experimental evidences for the hepatoprotective activity of the stem of Euphorbia royleana Linn. Material and Methods: The herbs of Euphorbia royleana Linn (stem...