Formulation and evaluation of Acyclovir microparticles for Ocular Delivery
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2016, Vol 4, Issue 2
Abstract
The objective of the present work was to formulate and evaluate microparticles of Acyclovir and produced sustained drug delivery for ocular delivery. In this 9 batches(A1-C3) of acyclovir microparticle was prepared with ethyl cellulose, PVA and other ingredients by solvent evaporation technique. The prepared microparticles were evaluated for different parameters i.e % Drug yield, % Drug entrapment, Surface morphology, Zeta potential and in-vitro drug release for 24hrs in phosphate buffer 7.4 and simulated tear fluid. The best batch was performed stability studies for 6 months. The research concluded that Acyclovir microparticles could be a alternative for conventional dosage formand other phytochemical in herbs.
Authors and Affiliations
Shekhar Singh| School of Pharmacy, OPJS University, Churu, Rajasthan, India, Anil Middha| School of Pharmacy, OPJS University, Churu, Rajasthan, India, Randhir Singh Dahiya| College of Pharmacy, MMU, Ambala, Haryana, India
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