FORMULATION AND EVALUATION OF AMLODIPINE TRANSDERMAL PATCHES USING ETHYL CELLULOSE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 10
Abstract
The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as ethyl cellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by using polymers like ethylcellulose 1 %, 1.5 %, 2 % and 2.5 % and a total of eight formulations were prepared. Plasticizers used were propylene glycol and dibutylpthalate. The transdermal patches were evaluated for their physicochemical properties like folding endurance, thickness, percentage moisture loss, percentage moisture absorption, drug content and water vapour transmission rate. The diffusion studies were performed by using franz diffusion cell. Formulation E6 (1.5 % Ethylcellulose with dibutylphthlate) as plasticizers showed a maximum release of 99 % in 24 hours. Out of these eight formulations of EC, 1.5 % Ethylcellulose (E6) was optimized since they produced a sustained and a complete release over a period of 24 hours. Thus the knowledge on the use of ethyl cellulose to control drug release in transdermal delivery systems might be applicable to other transdermal drug delivery system as well.
Authors and Affiliations
Lincy john, Arun Kumar , Sandra Samuel
Keywords
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- EP ID EP131076
- DOI 10.7897/2230-8407.041019
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