Formulation and evaluation of biphasic Delivery system of aceclofenac mini-tablets in Hard gelatin capsules
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2013, Vol 3, Issue 2
Abstract
Investigated the feasibility of formulating a biphasic delivery system usingmini-tablets in hard gelatin capsules delivering drug with a variety of release profiles.Aceclofenac (NSAID analgesic) were chosen as model drug. Immediate release minitablets(IRMT) were manufactured by direct compression using microcrystallinecellulose and cross carmellose as a superdisintegrant, each mini-tablet containingapproximately 25 mg Aceclofenac (AFC). Sustained release mini-tablets (SRMT) wereformulated using various ratios of HPMC K4M and HPMC K100M. Capsules werefilled with individual mini-tablets to deliver 100 mg of AFC. The IR and SRMT werecombined in the capsule designed to provide a pulsatile or multi-phase delivery ofdrug as immediate and sustained dissolution release profiles. Capsules containingAFC immediate release mini-tabs were shown to release nearly 100% of the drugwithin 60 minutes. Capsules containing SRMT released 98 % of AFC over 12 hours.The feasibility of delivering a drug in biphasic immediate sustained release mannerwas reputable by combining mini-tablets in a hard gelatin capsule.
Authors and Affiliations
D Karthikeyan, A Vijayalaxmi, C Santhosh Kumar
Keywords
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