FORMULATION AND EVALUATION OF CANDESARTAN CO-PRECIPITATE WITH HYDROPHILIC POLYMERS; PREPARATION OF ORODISPERSIBLE TABLETS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 5
Abstract
Candesartan cilexetil is an angiotensin-receptor blocker that suffer from inadequit and variable oral bioavailability due to its poor aqueous solubility and presystemic metabolism. Therefore, the objectives of this study was to enhance candesartan cilexetil dissolution with subsequent preparation of mouth dispersable tablets. The drug was precipitated from its ethanolic solution over Aerosil 200 as carrier for the deposited microcrystals. To improve surface wettability, the precipitation step was performed in presence of hydrophilic polymer. The selected polymers were polyvinylpyrrolidone 40T (PVP), hydroxypropylmethyl cellulose E5 (HPMC), Poloxamer 407 and polyethylene glycol6000 (PEG). The products were evaluated regarding dissolution pattern. Physical characterization was also evaluated for selected formulations. Thermal behaviour and X-ray powder diffraction results confirmed reduced drug crystalinity. Infra-red spectroscopy indicated drug-excipient compatibilty. All formulations showed imrovement in drug dissolution compared to pure drug. Presence of polymer resulted in higher initial release and dissolution efficiency. Best formulations regarding dissolution were successifly used in the preparation of oral dispersible tablets with fast drug release. Drug precipitation over carrier with large surface area in presence of hydrophilic polymer is a promising approach for enhancing dissolution rate of poorly soluble drugs.
Authors and Affiliations
Asmaa M. Dewedar
Keywords
Related Articles
- EP ID EP670695
- DOI -
- Views 201
- Downloads 0
SEGMENTAL AND/OR SUBSEGMENTAL ANATOMY OF THE ANTERIOR SECTOR IN HUMAN LIVER
Background. New concepts of liver functional anatomy were proposed. Based on the further subdivision of the second-order portal branches the segments were subdivided into 6 to 8 cone shaped units. The anterior sector seg...
EUGENOL AMELIORATES LETROZOLE INDUCED POLYCYSTIC OVARY SYNDROME IN RATS
Background: It is now evident that there is a strong association between oxidative stress and chronic low grade inflammation in polycystic ovary syndrome (PCOS) pathogenesis. Therefore, simultaneous targeting of these pa...
PHARMACOLOGICAL STUDY OF NAGAKESARA WITH RESPECT TO ITS STONITASTHAPANA KARMA WITH SPECIAL REFERENCE TO ITS HAEMOSTATIC ANaD WOUND HEALING PROPERTIES
Nagkesara was named on the most effective useful part of the tree i.e. stamen of the tree flowers. It is found at the eastern and southern parts of India. It has many good properties, amongst which the Raktasthapana is v...
PERSISTENT RISE OF BHCG AFTER SURGICAL TREATMENT OF ECTOPIC PREGNANCY
Keycontent Bhcg measurements after treatment of ectopic pregnancy is justified to rule out persistent trophoblastic activity. Management of persistent rise of Hcg after surgical treatment of ectopic remains a clinica...
DERMAL AB-RIDGE COUNT: POSSIBLE MARKER FOR AUTISM
Dermatoglyphics as the study of epidermal ridges has been well known for personal identification and recently for the diagnosis of various genetic disorders. The study aimed at evaluating the AB- ridge count (ABRC) of au...