FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESSIVE MATRIX TABLETS OF LEVAMISOLE: ASSEMENT OF PURIFIED FRUIT PULP POLYSACCHARIDE ISOLATED FROM AEGLE MARMELOS AS MUCOADHESIVE EXCIPIENT

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4

Abstract

ABSTRACTObjective: Mucoadhesive tablets have been developed for Levamisole using natural mucoadhesive material such as purified polysaccharide isolated fromthe ripe fruit pulp of Aegle marmelos. Lin (AMPS) and evaluate in-vitro, in-vivo mucoadhesive properties to assess its efficacy as mucoadhesive agent.Method: The tablets were formulated with AMPS in different concentration employing wet granulation method. Pre-compression tests, tabletparametric tests, swelling index and In-vitro drug release kinetics were performed. Optimization of formulation was done on the basis of controlledand maximum amount of drug release with respect to time. In-vitro, ex-vivo evaluation of mucoadhesion was performed with all prepared formulationbut in-vivo evaluation was done by X-ray with optimized formulation (F40) in rabbit. Stability studies were carried out according to ICH guide linewith optimized formulation.Results: The tensile strength, mucoadhesive strength and swelling index increase as the natural polymer concentration increase. The releaseKinetics and mechanism of release were calculated by fitting in-vitro release data in various models demonstrating that release. In vitro drug releaseof the optimized batch (F40) was best fitted and explained by Korsemeyer–Peppas and zero order drug release; (Rp=0.9891) and (Ro=0.9842)showed highest linearity and n value 0.97>0.5<1. Hence, pattern of drug release by non-Fickian erosion controlled release. Studies of the optimizedformulation demonstrate no significant change in the tensile strength, mucoadhesive strength and drug assay.Conclusion: These research outcomes clearly specify the potential of the AMPS to be used as mucoadhesive, release retardent natural material intablet formulationKeywords: Polysaccharide, Acrylamidopropylmethane sulfonic acid, Aegle marmelos, Levamisole, Mucoadhessive.

Authors and Affiliations

Jashabir Chakraborty, Suvakanta Dash, Biswajit Das

Keywords

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  • EP ID EP605799
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How To Cite

Jashabir Chakraborty, Suvakanta Dash, Biswajit Das (2015). FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESSIVE MATRIX TABLETS OF LEVAMISOLE: ASSEMENT OF PURIFIED FRUIT PULP POLYSACCHARIDE ISOLATED FROM AEGLE MARMELOS AS MUCOADHESIVE EXCIPIENT. Asian Journal of Pharamceutical and Clinical Research, 8(4), 262-269. https://europub.co.uk/articles/-A-605799