FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing lomefloxacin hydrochloride in a non-biodegradable carrier for targeted delivery of drug. Polymer ethyl cellulose was used in the formulation of the dental films. The dental film was then evaluated for various parameters and in-vitro, in-vivo study. The effects of various formulation variables on the drug release profiles from the films were studied to determine optimum formulations. Drug release profile of dental film showed that the film exerted an initial burst release followed by sustained release of the drug and the drug release was well above the minimum inhibitory concentration throughout the time of study. The study suggests that non-biodegradable polymer based dental film of lomefloxacin hydrochloride is a potential local drug delivery device for the treatment of periodontitis.
Authors and Affiliations
Aviral Katiyar , S. K. Prajapati , Ali Akhtar , Sanjay Vishwakarma
Keywords
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