FORMULATION AND EVALUATION OF DORSOLAMIDE HCL OCULAR INSERT
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
Matrix type of ocular insert was prepared using hydrophilic polymer PVP K 30 in different concentration by solvent casting method. The compatibility study of drug and polymer was performed by FTIR and DSC study and results revealed that drug and polymer are compatible to each other. Physicochemical evaluations like weight variation, thickness, content uniformity, moisture absorption, moisture loss test were performed. In vitro release study was carried out for all formulations and overall results revealed that as concentration of polymer increases there was slow release of Dorsolamide HCl occurred from the formulation.
Authors and Affiliations
TK Ghelani, AK Seth, V Saini, S. Singhal, S Kumar, YC Yadav
Keywords
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