FORMULATION AND EVALUATION OF FAST DISPERSIBLE TABLETS OF CITALOPRAM HYDROBROMIDE
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2013, Vol 3, Issue 12
Abstract
A Fast dispersible tablets disintegrate either rapidly in the oral cavity without the need of water or chewing. Citalopram hydrobromide is a highly selective serotonin reuptake inhibitor with minimal norepinephrine and dopamine neuronal reuptake and Tolerance to the 5-HT selective inhibitor. It is frequently used off-label to treat anxiety greatly reduce the symptoms of diabetic neuropathy and premature ejaculation and effective in the treatment of post- stroke pathological crying. It is estimated that 12% of the population affected by this problem. In order to calm the anxiety disorder the present study was aimed to formulate fast dispersible tablets to resolve the difficulties of pediatric and geriatric patients. The tablets were prepared by direct compression method using different superdisintegrants with different concentration such as Crosscarmellose sodium, crospovidone and sodium starch glycolate for their suitability in terms of drug release efficiency. 12 formulations having superdisintegrants alone and its combination at different concentrations (7.5, 10, 12.5 mg) were prepared. Effect of superdisintegrant on wetting time, dispersion time, drug content and in vitro release has been studied. Tablet containing crosscarmellose sodium showed excellent in vitro dispersion time and drug release as compared to other formulations. After study of nine formulations CP4 to CP6 showed fast dispersion time and maximum drug release in 7min and 5 min respectively. It was concluded that the fast‐dispersible Citalopram tablets could be prepared by direct compression method using crosscamellose sodium superdisintegrants for effective therapy
Authors and Affiliations
Ramu Ankapur Vakidi, UmamaheswaraRao G, Prabakaran L
Keywords
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