FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS CONTAINING LOSARTAN POTASSIUM.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 6
Abstract
The fast dissolving oral film were prepared using different polymers like PVA, PVP, HPMC, Carbopol, Pectin and Tragacanth by solvent casting method. The fast Dissolving oral film evaluated for folding endurance, swelling index, surface pH, in vitro disintegration time, drug content, drug polymer compatibility by FTIR Study, Scanning electron microscopy and in vitro drug release. The physical appearance and folding endurance properties were found to be good and electron microscopy shows that films are clear, colourless with smooth surface without any scratches .The average folding endurance time within the range of 112 to 208.The drug content showed uniform mixing of drug in all prepared fast dissolving films. The invitro drug release showed 78 to 96 % drug release within 5 minutes. Drug release obeys the first order kinetics. The prepared films were stable. Hence it can be inferred that the fast dissolving oral film of losartan potassium may produce the rapid action thereby improving bioavailability and enhance the absorption by avoiding the first pass effect. Keywords: Losartan Potassium, PVA, HPMC, fast dissolving film.
Authors and Affiliations
Deepak Kumar Sarangi, Suman Kumar Mekap and Monalisa Mahapatra.
Keywords
Related Articles
- EP ID EP612488
- DOI 10.21474/IJAR01/9312
- Views 37
- Downloads 0
AUDIT OF THE THERMO-SENSITIVE DRUGS CIRCUIT AT UNIVERSITY HOSPITAL CENTER OF BRAZZAVILLE (CHUB).
The hospital pharmacist manages drugs and must ensure that the drug storage conditions including thermo-sensitive drugs which are under his responsibility, are respected. The repeated power outages make the drug security...
CLINICAL AND BIOCHEMICAL EVALUATION OF THYMOQUINONE GEL IN THE TREATMENT OF CHRONIC PERIODONTITIS.
Aim of study: toinvestigate the effect of Thymoquinone gel on the clinical periodontal parameters as well as the level of IL-1β and total anti-oxidant capacity levels in gingival crevicular fluid of chronic periodontitis...
MAGNETIC AND DIELECTRIC CHARACTERISATION OF PANI - COBALT FERRITE NANO COMPOSITE SYNTHESIZED VIA GREEN MEDIUM.
In recent years, the development of efficient green chemistry methods for synthesis of nano particles has become a major focus of researchers. In this work polyaniline (PANI) -cobalt ferrite nano composite is prepared us...
A STUDY TO ASSESS THE EFFECTIVENESS OF YOGA THERAPY ON LEVEL OF HBA1C AMONG T-2 DIABETIC PATIENTS ADMITTED IN O.P.D AT SELECTED HOSPITAL,PUNJAB.
The study investigated the level of HbA1C for T-2 diabetic patients attending OPD in selected Hospital,Faridkot,Punjab.A quantitative research approach and Quasi experimental Time series design was used in this study.The...
SPONTANEOUS RENAL ALLOGRAFT RUPTURE OF UNKNOWN ETIOLOGY: A CASE REPORT.
Introduction: Rupture of renal allograft is a rare but serious complication of transplantation. This is usually attributed to acute rejection, acute tubular necrosis, or renal vein thrombosis.Some other causes like renal...