FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS CONTAINING LOSARTAN POTASSIUM.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 6
Abstract
The fast dissolving oral film were prepared using different polymers like PVA, PVP, HPMC, Carbopol, Pectin and Tragacanth by solvent casting method. The fast Dissolving oral film evaluated for folding endurance, swelling index, surface pH, in vitro disintegration time, drug content, drug polymer compatibility by FTIR Study, Scanning electron microscopy and in vitro drug release. The physical appearance and folding endurance properties were found to be good and electron microscopy shows that films are clear, colourless with smooth surface without any scratches .The average folding endurance time within the range of 112 to 208.The drug content showed uniform mixing of drug in all prepared fast dissolving films. The invitro drug release showed 78 to 96 % drug release within 5 minutes. Drug release obeys the first order kinetics. The prepared films were stable. Hence it can be inferred that the fast dissolving oral film of losartan potassium may produce the rapid action thereby improving bioavailability and enhance the absorption by avoiding the first pass effect. Keywords: Losartan Potassium, PVA, HPMC, fast dissolving film.
Authors and Affiliations
Deepak Kumar Sarangi, Suman Kumar Mekap and Monalisa Mahapatra.
Keywords
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- EP ID EP612488
- DOI 10.21474/IJAR01/9312
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