FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALDECOXIB
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2018, Vol 7, Issue 6
Abstract
Valdecoxib is a selective COX- II inhibitor with anti – inflammatory, analgesic and antipyretic properties. The poor aqueous solubility of the drug leads to variable dissolution rates. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate. The fast dissolving tablets of Valdecoxib was prepared with some carriers (polymers) and super disintegrants such as Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone NF and β – Cyclodextrin. The above mentioned all carriers and superdisintegrants were taken in different proportions of 5, 10, and 15%. All the formulations of the fast dissolving tablets of Valdecoxib were prepared by direct compression technique. The blend was examined for Angle of repose, Bulk density, Compressibility index and Hausner’s ratio. The prepared tablets were evaluated for hardness, drug content uniformity, friability, disintegration time and dissolution rate. An effective pleasant testing formulation released 99.88% drug within 10 minutes. The prepared formulations drug release was found to be comparable with the marketed dispersible tablets. Keywords: Fast dissolving tablets, Super-disintegrants, Valdecoxib, Crosspovidone, Sodium Carboxy Methyl Cellulose.
Authors and Affiliations
K Kareemuddin Ansari
Keywords
Related Articles
- EP ID EP487318
- DOI -
- Views 178
- Downloads 0
Therapeutic effect of quercetin on the complications of nicotinamide-streptozotocin induced type-2 diabetes in male rats
Introduction: Type-2 diabetes mellitus (T2DM) is a rapid growing epidemic disease, with a continually increasing prevalence that exhibit complications in different body organs. The nicotinamide-streptozotocin (NA-STZ) r...
Comparative Study for the Assessment of Compliance in Alcoholics and Non-Alcoholic Patients on Anti-tubercular Therapy – A Prospective Observational Study
Background: Compliance to Anti-tubercular therapy is very important for the treatment and also to prevent the relapse or failure of the treatment. Nevertheless, many people fail to adhere to the therapy and various facto...
The success rate of Endoflas powder mixed with Curcumin gel as obturating material in Primary Molars: Case- Series.
Introduction: Important requisites of an obturating material for primary teeth are that it should resorb at the same rate as the roots of a primary tooth, should be harmless to the periapical tissue and permanent tooth g...
ANTIBIOTIC RESISTANCE PATTERN OF BLOODSTREAM BACTERIAL ISOLATES FROM ENTERIC FEVER PATIENTS: A PROSPECTIVE CROSS-SECTIONAL STUDY
Background:Enteric fever continues to remain a major public health problem, especially in regions of South-East Asia due to poor sanitation and personal hygiene. Bangladesh open prone to enteric fever outbreaks and is an...
OCCLUSION THERAPY TREATMENT IN AMBLYOPIC EYE
Amblyopia is the most common visual disorder of childhood, yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. The MOTAS study investigated the dose-response relat...