FORMULATION AND EVALUATION OF FILM COATED TICLOPIDINE HYDROCHLORIDE IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
In the present work attempts were made to with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of film coated Ticlopidine Hydrochloride immediate release tablets by direct compression technique. The current study involves preparation and evaluation of Ticlopidine Hydrochloride tablets (250mg), comparison of dissolution rate of optimized formula with innovator’s product and estimation of similarity and difference factors. The three superdisintegrents used in the study were Cross carmellose sodium (CCS), Microcrystalline Cellulose (MCC) and Native starch. Six Tablet batches (F1 – F6) having superdisintegrents at different concentrations level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration test and invitro – dissolution study. The formulation F5 containing combination of CCS, MCC and native starch (6, 44.73 & 54.75 mg) showed similar invitro disintegration time and drug release as that of marketed product (Tyclid).
Authors and Affiliations
Pradeep Kumar, Chandra S , N. R Sivakumar , S. K Kanthlal , R. S. Jayaseelan
Keywords
Related Articles
- EP ID EP119706
- DOI -
- Views 85
- Downloads 0
FORMULATION AND EVALUATION OF EFFERVESCENT TABLETS OF ACECLOFENAC
Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly peo...
DECLININE: THE NEW ALKALOID FROM PHOEBE DECLINATA NEES
The new alkaloid named as declinine had been isolated from stem bark of Phoebe declinata Nees (Lauraceae). This alkaloid had been obtained for the first time from this plant. The structure of declinine was determined by...
EXPLORATION OF ANTIMICROBIAL POTENTIAL OF METHANOL EXTRACT OF STEMS OF EUPHORBIA NERIIFOLIA
The antimicrobial efficacy of methanol extract of stem of the plant Euphorbia neriifolia (Family: Euphorbiaceae) was evaluated against selected pathogenic bacterial strains (Staphylococcus aureus ATC-2245, Streptococcus...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE AND HYDROCHLOROTHIAZIDE IN TABLETS: APPLICATION TO DISSOLUTION STUDY
A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Amlodipine besylate and...
DESIGN AND DEVELOPMENT OF A NOVEL COLOR BIAS AVOIDED AND APPETITE CONDITIONING T-MAZE MODEL FOR EVALUATING THE MEMORY ENHANCING DRUGS IN ZEBRA FISH
Zebrafish is being used as a model for preclinical studies because of its unique innate physiological and behavioral aspects that almost correlate to the mammals including human. Many behavioral models have been develope...