FORMULATION AND EVALUATION OF FILM COATED TICLOPIDINE HYDROCHLORIDE IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
In the present work attempts were made to with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of film coated Ticlopidine Hydrochloride immediate release tablets by direct compression technique. The current study involves preparation and evaluation of Ticlopidine Hydrochloride tablets (250mg), comparison of dissolution rate of optimized formula with innovator’s product and estimation of similarity and difference factors. The three superdisintegrents used in the study were Cross carmellose sodium (CCS), Microcrystalline Cellulose (MCC) and Native starch. Six Tablet batches (F1 – F6) having superdisintegrents at different concentrations level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration test and invitro – dissolution study. The formulation F5 containing combination of CCS, MCC and native starch (6, 44.73 & 54.75 mg) showed similar invitro disintegration time and drug release as that of marketed product (Tyclid).
Authors and Affiliations
Pradeep Kumar, Chandra S , N. R Sivakumar , S. K Kanthlal , R. S. Jayaseelan
Keywords
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