FORMULATION AND EVALUATION OF FILM COATED TICLOPIDINE HYDROCHLORIDE IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
In the present work attempts were made to with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of film coated Ticlopidine Hydrochloride immediate release tablets by direct compression technique. The current study involves preparation and evaluation of Ticlopidine Hydrochloride tablets (250mg), comparison of dissolution rate of optimized formula with innovator’s product and estimation of similarity and difference factors. The three superdisintegrents used in the study were Cross carmellose sodium (CCS), Microcrystalline Cellulose (MCC) and Native starch. Six Tablet batches (F1 – F6) having superdisintegrents at different concentrations level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration test and invitro – dissolution study. The formulation F5 containing combination of CCS, MCC and native starch (6, 44.73 & 54.75 mg) showed similar invitro disintegration time and drug release as that of marketed product (Tyclid).
Authors and Affiliations
Pradeep Kumar, Chandra S , N. R Sivakumar , S. K Kanthlal , R. S. Jayaseelan
Keywords
Related Articles
- EP ID EP119706
- DOI -
- Views 87
- Downloads 0
HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF ECBOLIUM VIRIDE (FORSSK.) ALSTON ROOTS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY
In the present study, the methanolic extract of Ecbolium viride root was evaluated for its hepatoprotective effect against CCl4 induced hepatic injury in rats. Alteration in the levels of biochemical markers of hepatic d...
EFFICACIOUS STUDY OF IKSHURAK (ASTERACANTHA LONGIFOLIA) KSHARA IN THE MANAGEMENT OF THE GALL STONE (CHOLELITHIASIS) WITH VARIOUS VEHICLES
Gall bladder stone (Cholelithiasis) is one of the commonest among the major gallbladder disease, affecting large population of community. In untreated cases it may lead to numerous complications. The clinicians and scien...
A CLINICAL STUDY ON AJMODADI CHURNA AND ERANDA TAILA IN THE MANAGEMENT OF AMAVATA (RHEUMATOID ARTHRITIS)
Despite amazing diagnostic techniques and medicines, our society is suffering from unpreventable epidemics of heart diseases, cancers, rheumatoid diseases and other autoimmune diseases. Amavata is a crippling disease cau...
FORMULATION AND EVALUATION OF AMLODIPINE TRANSDERMAL PATCHES USING ETHYL CELLULOSE
The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as ethyl cellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by usin...
ANTICANCER ACTIVITY OF HYDROALCOHOLIC EXTRACTS FROM PARIS POLYPHYLLA RHIZOMES AGAINST HUMAN A549 LUNG CANCER CELL LINES USING MTT ASSAY
The following study is designed to determine the anticancer and cytotoxic potential of hydroalcoholic extract from rhizomes of Paris polyphylla to produce any cytotoxic effect on human A549 lung cancer cell lines. The hy...