Formulation and Evaluation of Flubiprofen Emulgel by Using Different Concentration CARBOPOL 974P
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 2
Abstract
Abstract:The aim and objective of this study was to formulate and evaluate the Flurbiprofen emulgel as a topical drug delivery which is a novel and advantageous delivery system forhydrophobic drugs to systemic circulation via skin. Flurbiprofen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) used to treat Rheumatoid Arthritis (RA). Emulgel is one of the most interesting topical delivery system. In spite of many advantages of gels a major limitation is to deliver the hydrophobic drugs. Emulgel is used topically because of its characteristic dual control release (i.e.) emulsion as well as gel it demonstrates better drug release as compared to other topical drug delivery systemdue to excess of oil bases and lack of insoluble excipients. In present work Flurbiprofen emulsion was prepared by using liquid paraffin and white soft paraffin as an oil phase prepared emulsion was gelled with different concentrations of Carbopol 974p. All 6 formulations were evaluated for Homogenicity, Extrudability, pH, Viscosity, Spreadability, swelling index, drug content determination &Invitro dissolution test out of 6 formulation F4 is optimized based on the results and optimized formulation is good at stability conditions. Keywords:Flurbiprofen, NSAID, Rheumatoid Arthritis, CARBOPOL 974 P, Homogeneity, extrudability, pH, viscosity, Spreadability, swelling index, drug content determination & Invitro dissolution test.
Authors and Affiliations
M Swetha, J. N Suresh Kumar, Dr. Satyavathi, B. Mohan
Keywords
Related Articles
- EP ID EP397226
- DOI -
- Views 130
- Downloads 0
Evaluation of Indoor Vector Surveillance Regarding Dengue in Shahdara, Lahore
Abstract: The objectives of the study are to find out the evaluation of dengue indoor vector surveillance done by the teams of Shahdara, Lahore and awareness of health hazards of dengue fever. It was a cross sectional de...
Synthesis of Possible Anti-Cancer and Anti-Mycobacterial Fluoro Substituted Sulphonamide Benzothiazoles Comprising Potent Thiazolidinone
Abstract: In the present study, a series of N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(3-nitrophenyl)-4-oxo-thiazolidin-3-yl]benzenesulphonamide and N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(4-ni...
Observational Study of Prescribing Pattern of Psychotropic Drugs Used in Department of Psychiatry at Tertiary Level Hospital
Mental health disorder is one of the major health problems, which requires early & effective treatment. WHO global burden of disease 2001 estimates four main psychiatric causes leading to disability, which is Depression,...
Prevalence of musculokseletal pain among dentist: a cross-sectional study
Abstract: Around the globe, occupational-related diseases are widespread and common. Posture during work and duty hours are the major risk factor in the development of musculoskeletal disorder. The rationale behind the s...
Apert syndrome with cryptorchidism and recurrent hemoptysis
Abstract: We present the case of 30 year old male patient of Apert Syndrome with cryptorchidism and recurrent life threatening hemoptysis. Subsequent investigations revealed bronchiectasis. We would like to highlight t...