Formulation and Evaluation of Flubiprofen Emulgel by Using Different Concentration CARBOPOL 974P
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 2
Abstract
Abstract:The aim and objective of this study was to formulate and evaluate the Flurbiprofen emulgel as a topical drug delivery which is a novel and advantageous delivery system forhydrophobic drugs to systemic circulation via skin. Flurbiprofen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) used to treat Rheumatoid Arthritis (RA). Emulgel is one of the most interesting topical delivery system. In spite of many advantages of gels a major limitation is to deliver the hydrophobic drugs. Emulgel is used topically because of its characteristic dual control release (i.e.) emulsion as well as gel it demonstrates better drug release as compared to other topical drug delivery systemdue to excess of oil bases and lack of insoluble excipients. In present work Flurbiprofen emulsion was prepared by using liquid paraffin and white soft paraffin as an oil phase prepared emulsion was gelled with different concentrations of Carbopol 974p. All 6 formulations were evaluated for Homogenicity, Extrudability, pH, Viscosity, Spreadability, swelling index, drug content determination &Invitro dissolution test out of 6 formulation F4 is optimized based on the results and optimized formulation is good at stability conditions. Keywords:Flurbiprofen, NSAID, Rheumatoid Arthritis, CARBOPOL 974 P, Homogeneity, extrudability, pH, viscosity, Spreadability, swelling index, drug content determination & Invitro dissolution test.
Authors and Affiliations
M Swetha, J. N Suresh Kumar, Dr. Satyavathi, B. Mohan
Keywords
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