FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF STAVUDINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
The present study was designed to formulate and evaluate hydro dynamically balanced Floating Drug Delivery Systems as controlled release modules, which prolongs the release rate of the drugs. Stavudine is an anti- retroviral, reverse transcriptase inhibitor (Nucleoside). Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. Formulation of Stavudine as gastro retentive drug delivery systems (GRDDS) is especially advantageous over other prolonged type drug delivery systems and conventional tablets because the drug is having absorption window in the duodenum and jejunum level and having relatively short half life. Stavudine was taken as the model drug to optimized formulations was prepared. The floating ability of lipoidal fatty polymers Gelucire 13/01, Gelucire 43/ 01 is compared over various polymers like HPMC, HPMC K4M, Ethocel, Sodium carboxy methyl cellulose. The drug: polymer ratios used to prepare the different formulations were 1:0.5 and 1:1. Blend of all the formulations are prepared by melt granulation technique. All the tablets were subjected for dissolution study using USP dissolution apparatus (USP XXIII paddle method) and data were analyzed at 265nm. The drug release of Stavudine from all the formulations followed zero order kinetics. According to the dissolution profiles of formulations drug retardation was enhanced in 1:1 Drug: Polymer proportion than 1:0.5 proportions. Of all the formulations in which Gelucire 13/01 is used as a floating polymer, has retarded the drug successfully upto 12 hours.
Authors and Affiliations
Vijaya Voleti. , Harun Shaik. , N. Raghu Ram, G. Silpa rani, Srinivasa Rao
Keywords
Related Articles
- EP ID EP140198
- DOI -
- Views 103
- Downloads 0
IN VITRO ANTIBACTERIAL ACTIVITIES STUDY OF POLYMERIC CIPROFLOXACIN SUSPENSIONS
To study the in vitro antibacterial activities of mucoadhesive suspensions containing Ciprofloxacin, three different formulations were prepared by using three polymers, such as Hydroxypropyl methylcellulose (HPMC) (S1),...
VALIDATED SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND FURAZOLIDONE IN PURE AND IN TABLET DOSAGE FORM
Two methods are developed for simultaneous estimation of metronidazole and furazolidone in pure and in tablet dosage form by using distilled water as a solvent. Quantitation was carried out by the proposed methods namely...
A NOVEL FLOATING DRUG DELIVERY SYSTEM
Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Therefore, gastroretentive drug delivery systems (GRDDS) have been developed, which prolong the gastric emptying time. Several techn...
A STUDY ON PRESCRIBING PRACTICE AND GENERAL TRENDS OF DIABETES AMONG PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL
Diabetes mellitus is a clinical syndrome considered, one of the emerging threats of the 21st century. The aetiology of diabetes are multifactorial which includes the genetic factors that are coupled with environmental f...
SYNTHESIS OF NEW 1, 3, 7, 8-TETRASUBSTITUTED XANTHENES ANALOGUE
Theophylline, a methyl xanthenes compound, is known as an efficient bronchodilator drug, having also anti-inflammatory and immunomodulatory effects. In order to improve its pharmacological profile and to reduce also the...