Formulation and Evaluation of Gastroretentive Floating Matrix Tablets of Metronidazole using a Novel Non-effervescent Technique
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 2
Abstract
Abstract:The aim of this study was to formulate a novel non-effervescent gastro-floating drug delivery system of metronidazole using non-effervescent (sublimation and sintering) technique. Granules were prepared by wet granulation technique using varying concentration of Grewiamollis gum; 2,4,6,8% w/w admixed with 1%w/w acrylate methacrylate copolymer (Eudragit® RL100) and extra 2%w/w batch without the addition of Eudragit® RL100. Ammonium bicarbonate (30%w/w) was used as the sublimating agent. The granules were characterized for micromeritic properties. Thereafter, the granules were compressed at 30 units on the arbitrary scale load of a single punch tableting machine and the physicotechnical properties were determined. The metronidazole tablet was then sintered at 70oC for 12 h. Drug-excipient compatibility study was done using Fourier Transform Infra-red Spectroscopy (FTIR). All granules were free flowing and compressible. The metronidazole tablets had no floating lag time showing that tablets floated instantaneously. The in vitro buoyancy test of metronidazole tablet formulated using varying concentrations of Grewiamollis gum and Eudragit® RL100 was > 12 hr. The % maximum release (m∞) and time to achieve it i.e. (t∞) for metronidazole tablets were ≥88% and≥10 h respectively. FTIR studies showed that the excipients and the Active Pharmaceutical Ingredient (API) i.e. metronidazole were compatible. Grewiamollis gum has been investigated in the formulation of gastroretentive floating matrix tablet of metronidazole using sublimation and sintering technique (Non-effervescent method) which may find useful application in sustained release drug delivery particularly for drugs with short biological half-life that require frequent administration. Keywords:Non-effervescent, floating, Grewiamollis, metronidazole, ammonium bicarbonate and sublimation.
Authors and Affiliations
Airemwen CO
Keywords
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