FORMULATION AND EVALUATION OF GLIMEPIRIDE PATCHES FOR TRANSDERMAL DRUG DELIVERY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 6
Abstract
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use and improved patient compliance. “Glimepiride is an anti-diabetic drug with a shorter half life of ~5 hours, low bioavailability and extensive first pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as transdermal drug delivery system.” The present study was to formulate and evaluate transdermal drug delivery system of Glimepiride using polymers such as HPMC & Eudragit RS100 by solvent casting technique. Central composite design (CCD) was applied by using design-expert to optimize composition of HPMC and ERS100 for Transdermal Drug Delivery. The prepared formulations were evaluated for different physicochemical characteristics like Weight Variation, Folding Endurance, Flatness, pH of patches, % Moisture Content, % Moisture uptake, % Elongation, % Drug Content & % Drug Release. The drug release characteristics of the formulation were studied in-vitro by using semi-permeable membrane. The in-vitro drug release plot “showed “ that the drug release followed zero order kinetics & Higuchi model, which was evidenced from the regression values. Based on the drug release and physicochemical values obtained from the formulation F3 is considered as an optimized formulation which shows higher percentage of drug release (97.33±0.26% at 24 hour) with diffusion mediated mechanism. Korsmeyer-Peppas exponential plots shows fairly linear add, it is well supported by their regression coefficient values & slope value (n) were more than 1 which suggest that drug was released by Super Case-II transport. Key words: Transdermal Patches, Transdermal Drug Delivery, Glimepiride, Solvent Casting Method, Central Composite Design & Anti- Diabetic Patches.
Authors and Affiliations
RAHUL SHIVAJIRAO SOLUNKE
Keywords
Related Articles
- EP ID EP418066
- DOI -
- Views 171
- Downloads 0
Drug Utilization Pattern of Anesthetics in a Tertiary care Hospital
Background: Anesthesia means ‘loss of sensation’. Medications that cause anesthesia are called anesthetics. Anesthetics are used during tests and surgical operations to induce sleep, which prevents pain and discomfort an...
Immunoprecipitation of 11 ZN fingers Domains, CTCF and BORIS to Multifunctional Y-box DNA/RNA-binding factor, YB-1 in Glioma-RGBM
CCCTC binding factor (CTCF) is a unique highly conserved and ubiquitously expressed 11 zinc finger (ZF) transcriptional factor with multiple target site. It is able to bind to various target sequences to perform differen...
The success rate of Endoflas powder mixed with Curcumin gel as obturating material in Primary Molars: Case- Series.
Introduction: Important requisites of an obturating material for primary teeth are that it should resorb at the same rate as the roots of a primary tooth, should be harmless to the periapical tissue and permanent tooth g...
Impact of Autoclave Sterilization on Microstructure of Two Niti Endodontic Rotary File Systems: A Differential Scanning Calorimetric Analysis.
Introduction: Autoclaving is the most common and most efficient sterilization method used to sterilize endodontic files. But the effect of heating and cooling cycle’s occurring during sterilization on the physical and me...
In-Vitro Release Kinetics of Clonazepam from Five Brands of Clonazepam Available in Bangladesh Using UV Spectroscopic Analysis in Deionized Water Media
Background and Objective: The purpose of this study was to determine the in vitro release kinetics of five brands of Clonazepam tablets available in the local pharmaceutical market of Bangladesh. Methodology: In this stu...