FORMULATION AND EVALUATION OF IBUPROFEN SUPPOSITORIES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 6
Abstract
In this work suppositories containing Ibuprofen were prepared using water soluble bases (hydrous PEG and anhydrous PEG) and oil soluble bases (Suppocire AML, cacao butter, Witepsol E-75, Witepsol H-15, Novata DE-75, Suppocire AM, and Cacao butter). The prepared suppositories were evaluated for the parameters: weight variation, hardness, melting point, disintegration, melting point and drug content. In vitro drug release study was performed using USP type I apparatus in Sorensen's phosphate buffer pH 7.4 as dissolution media. Results showed that suppositories prepared using water soluble bases were within permissible range of all physical parameters. In vitro drug release from water soluble was greater than that from oil soluble bases. Suppocire AML, Cacao butter, Witepsol E-75 and Witepsol H-15 bases showed the highest values for the released ibuprofen among the tested bases. The lowest amount of drug released was observed with Novata DE-75 base. The study showed that the quality of suppositories is controlled by the type of base used.
Authors and Affiliations
Mosbah A. El-Majri , Mokhtar M. El-Baseir
Keywords
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