FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF DASATINIB USING CROSS POVIDONE
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 2
Abstract
Objective: The present investigation is concerned with development and evaluation of immediate release tablets containing Dasatinib drug a selective tyrokinase inhibitor (TKI) which is used in the treatment of chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) using cross povidone as super disintegrants to improve its bioavailability and dose-related side effects. Methods: The tablets were prepared by wet granulation method using various excipients, drug and super disintegrant such as cross povidone. The prepared tablets were evaluated for pre-compression parameters, post compression parameters, in vitro drug dissolution study and stability study. Results: Fourier Transform Infrared spectroscopy (FTIR) confirms no drug excipients interaction from various batches. Among the prepared formulations F5 Batch shows 89.99 % drug release in 45minutes.The best formulation F5 batch indicates no significant changes from short-term stability studies(at 40±2ºC/75±5% RH).Conclusion: Hence it was concluded that the best formulation F5 was suitable for all evaluation parameters and showed good results.
Authors and Affiliations
Chinmaya Keshari Sahoo, Dr. M Sudhakar, D VENKATA RAMANA, SATYABRATA BHANJA, Uttam Prasad Panigrahy
Keywords
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