FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF FLUNARIZINE DI-HYDROCHLORIDE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 2
Abstract
Immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer, has quick onset of action, economical and lead to better patient compliance. The aim of the present study was to prepare an immediate release tablet of Flunarizine di-Hydrochloride for the effective treatment of migraine. Tablets were formulated using various concentrations of croscarmellose sodium as superdisintegrant. A total eight formulations were prepared. All formulation were satisfactory for physical appearance including size, shape, thickness and other evaluation factors like weight uniformity, disintegration time, friability, hardness, drug content and in-vitro drug release. The tablet disintegration time was found to be less than 1min for the optimum batch. In vitro drug release was found maximum in F8 formulation which is 97.75±0.43 %. The optimized formulation also showed satisfactory size, shape, thickness and other evaluation factors like weight uniformity (177.77 ± 0.59 mg), disintegration time (37 ± 0.42 sec) , friability (less than 1%), hardness (3.0 kg/m2), drug content (100.21±0.99%).
Authors and Affiliations
Chauhan BS*| Jaipur College of Pharmacy, Jaipur, Rajasthan, India., Jha RK| Jaipur College of Pharmacy, Jaipur, Rajasthan, India., Jaimini M| Jaipur College of Pharmacy, Jaipur, Rajasthan, India., Sharma SK| Jaipur College of Pharmacy, Jaipur, Rajasthan, India.
Keywords
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