Formulation and Evaluation of Immediate Release Tablets of Zaltoprofen
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 5
Abstract
Zaltoprofen is a nonsteroidal anti-inflammatory drug (NSAIDs) with powerful analgesic action on inflammatory pain. The purpose of this research work was to formulate an immediate release tablet of Zaltoprofen for the treatment of pain and inflammation, by using superdisintgrant such as Croscarmellose sodium and different grades of microcrystalline cellulose. Immediate release tablets of Zaltoprofen were prepared by direct compression method using superdisintgrant such as Croscarmellose sodium and different grades of microcrystalline cellulose in different ratios. Sodium starch glycolate was added to aid disintegration. Tablets were subjected to physicochemical characterization such as thickness, hardness, friability, weight uniformity, drug content, disintegration time, in vitro drug release, and stability study. Tablets were found to be satisfactory when evaluated for thickness, hardness, friability, weight uniformity, drug content, disintegration time and in vitro drug release. The tablet disintegration time was less than one minute for all the tablet formulations. The in vitro drug release in optimized formulation F14 was found to be 98.89 % in 45 min. The optimized formulation F14 also showed satisfactory hardness (5.83±0.556 kg/cm2), friability (0.425%±0.0029), drug content (98.29%±0.0657), weight variation (270.21±0.2184 mg), disintegration time (25.02±0.0028seconds) and stability. Keywords: Pain and inflammation, Immediate release tablets, Superdisintegrants, NSAIDs.
Authors and Affiliations
Mayank Bansal, Sumedha Bansal, Gopal Garg
Keywords
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