FORMULATION AND EVALUATION OF LEVODOPA EFFERVESCENT FLOATING TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Levodopa is an immediate precursor of dopamine used in treatment of Parkinsonism disorders. The Levodopa effervescent floating tablets were prepared by direct compression technique, using different low density polymers (POLYOX different grades) in various drug polymer ratios.Methods: The Levodopa effervescent floating tablets were prepared by direct compression method. The floating tablets were evaluated for friability, thickness, hardness, weight variation test, drug content, in vitro release and floating properties. The drug excipients compatability was evaluated by DSC and FT-IR study.Results: All the batches showed compliance with pharmacopoeia standards. Among all the formulation F4 containing PEO WSR 303 in 1:1 drug polymer ratio showed controlled drug release for 12h (99.15%) emerging as the best formulation and follow first order kinetics via, swelling, diffusion. An in vitro buoyancy study reveals that all batches showed good in vitro buoyancy. The DSC study revealed that there was no strong interaction between Levodopa and excipients. Stability studies were carried out for best formulation F4 (PEO WSR 303 in 1:1 drug polymer ratio) according to ICH guidelines. Stability studies (40±2oC/75±5% RH) for 3 month indicated that Levodopa was stable in floating tablets.Conclusion: Hence different grades of low density polymer (PEO) in various drug polymer ratios can be used to prepare Levodopa floating tablets for prolongation of gastric residence time with enhanced patient compliance.Â
Authors and Affiliations
K. Chaitanya, Sellappan Velmurugan
CURCUMIN ATTENUATES LEAD (Pb)–INDUCED NEUROBEHAVIORL AND NEUROBIOCHEMICAL DYSFUNCTION: A REVIEW
Lead is one of the common chemical elements that is assigned the symbol Pb which came from the Latin Plumbum. Pb is widely used in the field of coating, refine and glaze ceramics and pottery. It is still used in the prod...
FORMULATION DEVELOPMENT AND OPTIMIZATION OF TABLET CONTAINING COMBINATION OF SALAM (SYZYGIUM POLYANTHUM) AND SAMBILOTO (ANDROGRAPHIS PANICULATA) ETHANOLIC EXTRACTS
Objective: The present study was aimed at finding the appropriate type of a binder and a disintegrant which can be used formulate tablets containing a combination of two ethanol extracts of Syzygium polyanthum leaves and...
EFFECT OF NARINGENIN ON LIPIDS, LIPOPROTEINS AND LIPID METABOLISING ENZYMES IN 7,12-DIMETHYL BENZ(A)ANTHRACENE-INDUCED MAMMARY CARCINOGENESIS IN SD RATS
Objective: Mammary carcinoma is one of the most common and prominent cause of cancer-related death in women worldwide. The role of fatty acid synthesis and altered lipid metabolism in cancer progression was well establis...
STRESS DEGRADATION STUDIES AND DEVELOPMENT OF A VALIDATED RP-HPLC METHOD FOR DETERMINATION OF TIAGABINE IN PRESENCE OF ITS DEGRADATION PRODUCTS
Objective: To develop a simple and rapid isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method and validate as per ICH and USP guidelines for analysis of tiagabine in the presence of its degrad...
EVALUATION OF ANTI-OBESITY EFFECT OF AQUEOUS EXTRACT OF MUCUNA PRURIENS SEEDS ON RATS
Objective: Evaluation of the anti-obesity effect of aqueous extract of Mucuna pruriens seeds on rats.Methods: Male Sprague-Dawley (SD) rats were subjected to high-fat diet (HFD) for 12 wk. L-DOPA (12.5 mg/kg, p. o.) as s...