FORMULATION AND EVALUATION OF LEVODOPA EFFERVESCENT FLOATING TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Levodopa is an immediate precursor of dopamine used in treatment of Parkinsonism disorders. The Levodopa effervescent floating tablets were prepared by direct compression technique, using different low density polymers (POLYOX different grades) in various drug polymer ratios.Methods: The Levodopa effervescent floating tablets were prepared by direct compression method. The floating tablets were evaluated for friability, thickness, hardness, weight variation test, drug content, in vitro release and floating properties. The drug excipients compatability was evaluated by DSC and FT-IR study.Results: All the batches showed compliance with pharmacopoeia standards. Among all the formulation F4 containing PEO WSR 303 in 1:1 drug polymer ratio showed controlled drug release for 12h (99.15%) emerging as the best formulation and follow first order kinetics via, swelling, diffusion. An in vitro buoyancy study reveals that all batches showed good in vitro buoyancy. The DSC study revealed that there was no strong interaction between Levodopa and excipients. Stability studies were carried out for best formulation F4 (PEO WSR 303 in 1:1 drug polymer ratio) according to ICH guidelines. Stability studies (40±2oC/75±5% RH) for 3 month indicated that Levodopa was stable in floating tablets.Conclusion: Hence different grades of low density polymer (PEO) in various drug polymer ratios can be used to prepare Levodopa floating tablets for prolongation of gastric residence time with enhanced patient compliance.Â
Authors and Affiliations
K. Chaitanya, Sellappan Velmurugan
Keywords
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