Formulation and evaluation of matrix floating tablets of Norfloxacin and Tinidazole combination
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
Floating drug delivery systems have shown to be of better significance in controlling release rate for drugs having site specific absorption. The present study was an attempt to develop floating tablets Tinidazole and Norfloxacin which on oral administration prolongs its gastric residence time thereby increasing bioavailability, diminishing side effects and enhanced patient compliance. Norfloxacin an oral antibiotic and Tinidazole an oral antiprotozoal having narrow absorption window in the upper and lower part of gastrointestinal tract, was formulated as floating matrix tablet using gas generating agent sodium bicarbonate and hydrophilic polymer Hydroxy propyl methyl cellulose by wet granulation technique. These Studies on dissolution methods showed, the modified dissolution method as a better alternative to conventional method as it mimics the physiological conditions existing in gastrointestinal tract. Hence the objective of present study is to formulate Norfloxacin and Tinidazole floating tablets using swellable polymers.
Authors and Affiliations
M. Madhuri, B. Nagendra Babu, D. Jeevan Mani Babu
Keywords
Related Articles
- EP ID EP33449
- DOI -
- Views 275
- Downloads 0
EFFECT OF METHANOLIC EXTRACT OF ADENANTHERA PAVONINA LINN ON DALTON'S ASCITIC LYMPHOMA
The present study was undertaken to examine anticancer activity of Adenanthera pavonina L stem bark extract on Dalton's ascitic lymphoma (DAL) in male Swiss albino mice. Tumour was induced in mice by intraperitoneal in...
Measles virus: a perpetual challenge
Measles is a highly contagious respiratory virus infection, with typical clinical symptoms including maculopapular rash, fever, cough, coryza, and conjunctivitis. Measles is highly contagious 90% of people who haven't...
Need of drug discovery to cure Ebola fever
Hygienic environment is an important requisite for maintenance of good health. The term ‘hygiene’ includes not only the material environment but also personal hygiene. The importance of personal hygiene should continua...
Prevalence & comparison of Cigarette smoking habits among health care professional students
Smoking cigarette is by far the most important risk factor for oral cancer and pre cancer & its use is a medical addictive condition. Several meta-analyses of the impact of smoke free legislation have been published ov...
Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats
The aim of the present study is to evaluate the antiulcer activity of Clitorea ternatea leaves (Linn) in experimentally induced animal models. In this study the leaves of Clitorea ternatea was extracted with petroleum...