FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF METFORMIN HYDROCHLORIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
Metformin HCl is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. In the present study an attempt has been made to prepare fast dissolving tablets of Metformin HCl in the oral cavity with enhanced dissolution rate. The tablets were prepared with three superdisintegrants e.g:, Croscarmellose sodium, Sodium starch glycolate and Crospovidone. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and hausners ratio. The tablets were evaluated for hardenss, friability, disintegration time, dissolution rate,drug content, and were found to be within 1 min. It was concluded that the mouth dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants.
Authors and Affiliations
T. H. Shaikh , S. D. Bhise , D. M. Ligade , M. V. K Patil , R. D. Patankar
Keywords
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