FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF METFORMIN HYDROCHLORIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
Metformin HCl is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. In the present study an attempt has been made to prepare fast dissolving tablets of Metformin HCl in the oral cavity with enhanced dissolution rate. The tablets were prepared with three superdisintegrants e.g:, Croscarmellose sodium, Sodium starch glycolate and Crospovidone. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and hausners ratio. The tablets were evaluated for hardenss, friability, disintegration time, dissolution rate,drug content, and were found to be within 1 min. It was concluded that the mouth dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants.
Authors and Affiliations
T. H. Shaikh , S. D. Bhise , D. M. Ligade , M. V. K Patil , R. D. Patankar
Keywords
Related Articles
- EP ID EP135232
- DOI -
- Views 131
- Downloads 0
THE INFLUENCE OF SUCROSE ESTER SURFACTANTS AND DIFFERENT STORAGE CONDITIONS ON THE PREPARATION OF A NOVEL SWIETENIA MACROPHYLLA OIL NANO-EMULSION
Nano-emulsions are emulsions with uniform and extremely small droplet sizes, typically in the range of 20–200 nm. Nano-emulsion concept has attracted considerable attention in recent years for its application in personal...
IN VITRO ANTIOXIDANT ACTIVITY OF ANTIBACTERIAL METABOLITES FROM STREPTOMYCES SPECIES KSRO-04
Antioxidants have gained importance as pharmacological agents and have been consumed in various forms mainly as fruits, vegetables and dietary supplements. These antioxidants are majorly obtained from plant source or hav...
LIFESTYLE MODIFICATION PLAN AS PER AYURVEDA IN GERIATRIC
Majority of major chronic diseases relevant today are now being claimed to relate to the errors of lifestyle. Most of such diseases have prevention potential but they are difficult to cure once they really occur. Lifesty...
DESIGN DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE TABLET OF MONTELUKAST SODIUM
The purpose of this research was to prepare a modified release tablet of montelukast sodium. Montelukast sodium is Leukotriene antagonist which is rapidly absorbed after the oral administration. At first the drug was spr...
A NATURAL WAY TO KEEP DEPRESSION MILES AWAY
‘Depression matters because depressive victims matter’. Tamarindus indica (Caesalpiniaceae), popularly known as Imli, is a perennial evergreen tree with a spreading crown, feathery evergreen foliage and fragrant flowers....