FORMULATION AND EVALUATION OF NOVEL SUSTAINED RELESE CAPSULES OF TERBUTALINE SULPHATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Terbutaline sulphate is a direct acting sympathomimetic agent with predominantly β- adrenergic activity and a selective action on β2-receptors, which is widely used in the prophylaxis and control of asthma. In the present investigation, the empty gelatin capsules (body) were cross linked by exposing to the vapours of formaldehyde in order to extend the drug release. The drug was filled in to the cross linked capsules by using hand filling method. Macroscopical features revealed that drug was dispersed in the polymer matrix. The empty capsules were subjected for various physicochemical tests like appearance, dimension, identification, weight and moisture content. The prepared capsules were evaluated for their thickness, content uniformity, weight variation, disintegration and in-vitro dissolution. The average weight and thickness of all the capsules were uniform. In-vitro dissolution studies showed a burst release initially followed by a progressive fall and a constant release of the drug and extended up to 8 to 10 hours. Release kinetics of terbutaline sulphte from cross linked capsules followed the first order release profile.
Authors and Affiliations
Abdul Khan , Mohammed Ahmed , B Ramesh
Keywords
Related Articles
- EP ID EP114040
- DOI -
- Views 141
- Downloads 0
EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF ANNONA RETICULATA AGAINST ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN ALBINO WISTAR RATS
Urinary stone disorder has afflicted humankind since antiquity and can persist, with serious medical consequences, throughout a patient’s lifetime. The common component of urinary stone is calcium oxalate (CaOx). In spit...
LIMONIA ACIDISSIMA L. (WOOD APPLE) AS FEED ADDITIVE ENHANCED GROWTH PERFORMANCE, IMMUNE RESPONSE AND DISEASE RESISTANCE OF INDIAN MAJOR CARP, CATLA CATLA (HAM.) AGAINST AEROMONAS HYDROPHILA INFECTION
Disease management has become prominent in aquaculture due to emergence of antibiotic resistant pathogens and overuse of chemotherapeutic agents. One among the developmental strategies to control disease outbreak is by e...
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES
The reaction of o-phenylenediamine with anthranillic acid yield compound 2-(1H benzo[d]imidazol-2-yl) aniline (1). The compound (1) was condensed with Chloroacetyl chlorides in the presence of dry benzene to get compound...
DEVELOPMENT AND METHOD VALIDATION OF AESCULUS HIPPOCASTANUM EXTRACT
Aesculus hippocastanum is highly regarded for their medicinal properties in the indigenous system of medicine. The objectives of the present study include the validation of Aesculus hippocastanum extract. Authenticated e...
CLINICAL PRESENTATION AND ASSOCIATION AMONG TUBERCULOSIS PATIENTS; COHORT COMPARISON BETWEEN SMOKERS VERSUS NEVER-SMOKE IN PENANG, MALAYSIA
We aimed to compare the demographic and clinical characteristics with risk determination of TB patients who were smokers vs. non-smokers. The retrospective, observational & cross-sectional cohort survey was done to c...