FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF CANDESARTAN BY DIRECT COMPRESSION METHOD USING SUBLIMATING AGENTS
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
This research was to formulate and evaluate oral dispersible tablets (ODT) of Candesartan by direct compression technique using sublimation agents like Menthol and superdisintegrants Crospovidone, Sodium Starch Glycolate, Croscarmellose Sodium and taste masking agent mannitol. Nine different formulations of Candesartan were prepared by using different ratios of these ingredients by direct compression method. These tablets were characterized by hardness, thickness, weight variation, wetting time, disintegration time, water Absorption ratio, in vitro drug release. All batches of oral dispersible tablets were satisfactory in terms of dissolution profile. The hardness, wetting time, disintegration time were also shows the satisfactory results. The batches of all formulations, F2 batch of oral dispersible tablets was found to be 99.02% of drug release in 10 minutes. The F2 was the best of all nine formulations of oral dispersible tablets of candesartan. Bioavailability of candesartan can be increased by formulating it as oral dispersible tablet
Authors and Affiliations
P. Venkateshwar Reddy , Swagata Dutta Roy , G. Vasavi , N. Sri ram , Mahesh Yadev
Keywords
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