FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF GRANISETRON HYDROCHLORIDE USING DIFFERENT POLYMERS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 10
Abstract
GranisetronHydrochloride is an orally active, highly selective 5HT3 receptor antagonist used in the treatment of cancer chemotherapy induced nausea and vomiting. The present work aimed at preparing quick releasing films of Granisetron Hyrochloride with the purpose of developing a dosage form providing a very quick onset of action beneficial in managing several conditions of vomiting, aiding in the enhancement of bioavailability and convenient for administration without the problem of swallowing and need of water. Oral films of Granisetron Hydrochloride were prepared using Pullulan, HPMC E5 & HPMC E15 in different concentrations by solvent casting method. Initially placebo films were prepared and evaluated on certain physical parameters to optimize the type and concentration of the polymer. Formulations containing 5 & 7.5% of Pullulan & HPMC E15 showed the optimum results. In-vitro release studies revealed that formulation containing 5% Pullulan showed the maximum release of 92% in a matter of 90sec. Thus it was concluded that of the various polymers employed Pullulan has the excellent film forming property and the formulation S1(containing 5% Pullulan) was the best formulation. Formulation S1 was then subjected to various evaluation parameters and stability studies. All the results obtained were satisfactory. Thus, Fast dissolving films of Granisetron Hydrochloride were successfully developed.
Authors and Affiliations
Jyoti Aggarwal , Keshav Jindal , Gurpreet Singh
Keywords
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- EP ID EP122623
- DOI 10.7897/2230-8407.0610141
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