FORMULATION AND EVALUATION OF OXICONAZOLE MUCOADHESIVE NANOEMULSION BASED GEL FOR TREATMENT OF FUNGAL VAGINAL INFECTION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: The aim of the present study was to formulate and evaluate nanoemulsion-based gel of oxiconazole nitrate (OXZ) for the treatment of vaginal infection.Methods: The solubility of Oxiconazole nitrate in various oils, surfactant and co-surfactant, were done to identify the components of the nanoemulsion. Based on the solubility studies, isopropyl myristate (IPM) as oil, Cremophore EL as surfactant and ethanol as co-surfactant were selected for preparing nanoemulsion. Various nanoemulsions were prepared by using the spontaneous emulsification technique. The nanoemulsion area was determined by constructing of pseudo ternary phase diagrams. The formulated nanoemulsions were subjected to accelerated stability test. The nanoemulsion formulae that passed the stability test were characterized for its morphology, droplet size, conductivity and zeta potential. These optimized formulae were incorporated into the polymeric gel of carbopol 934 (CRB), hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (NaCMC) and xanthum gum (XGUM), then evaluated for pH, viscosity, bio-adhesion properties, spreadability and drug content. The in vitro release and antifungal activity of the nanoemulsion gel formulae compared with the commercial available product, tinox® cream, was carried out to judge their efficiency.Results: The optimal nanoemulsion formulae which composed of oil, surfactant: cosurfactant mixture (1:1 or 2:1), and water in ratio 5:45:50 showed the highest stability of nanoemulsion. All the nanoemulsion gel formulae showed higher release and antifungal activity than the marketed cream.Conclusion: The Oxiconazole nitrate nanoemulsion-based gel could be successfully promising formulation for the topical treatment of fungal vaginal candidiasis.Keywords: Nanoemulsion, Oxiconazole nitrate, Nanoemulsion-based gel, Vaginal candidiasis, Mucoadhesion
Authors and Affiliations
Abeer Khattab, Soha Ismail
Keywords
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