Abstract

The present study was aimed at preparing and evaluating Nanocrystals of Paclitaxel (PTX). Various nanocrystal formulations were prepared by nanoprecipitation method using, Povidone as stabilizers as polymer matrix in different molar ratios. The formulations were optimized based on their particle size and zeta potential. Those optimized formulations were then characterized for their surface morphology, assay, in vitro drug release profile, syringeability and injectability, dilution stability, solubility and stability studies. The PTX nanocrystals were rod, spherical, nearly spherical and elongated cylindrical crystals with a size ranging from 40 nm to 120 nm. The assay was found to be in the range of 99.562% to 103.25%. The zeta potential was found to be in the range of -29.6 to 34.5 mV. The release data was plotted for cumulative % drug release as a function of time. In vitro release study was analyzed using various mathematical models. The formulations exhibited burst release and later sustained drug release profile. F1 (PVP). Formulation showed prolonged drug release for 72hr.All the formulations could pass freely through the needle size of 13 mm and showed different levels of redispersibility at different time intervals. Accelerated stability studies were performed and the formulations were found to be stable.

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