FORMULATION AND EVALUATION OF PHARMACOSOMAL GEL LOADED WITH NSAID
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 7
Abstract
The design of the present research work is to formulate and Evaluate Naproxen loaded pharmacosomal gel. Naproxen loaded pharmacosomes were formulated by Ether injection method. Formulations of pharmacosomes from NF1 to NF9 are formulated by using various concentrations of phospholipid and organic solvents. The prepared formulations were evaluated for Drug Entrapment efficiency, Drug release, Drug content, Drug release kinetics and characterised for Zeta potential, Particle size and Scanning Electron Microscopy. Among all the formulations NF2 exhibited better drug release of 86.13% for 7hrs; better Entrapment efficiency of 83.2%; Drug content was found to be 92.36%. The formulation that showed better Entrapment efficiency, Drug content was selected and incorporated into carbopol gel for transdermal delivery of the drug. The prepared delivery system was evaluated for In-vitro drug diffusion studies and the drug release was found to be 84.5% at the end of 7 hours.
Authors and Affiliations
Kolar Kusuma
Keywords
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