FORMULATION AND EVALUATION OF POSITIVELY CHARGED SELF-EMULSIFYING DRUG DELIVERY SYSTEM CONTAINING IBUPROFEN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
One of the most persistent problems faced by the formulation scientists has been to find methods of improving the oral bioavailability of poorly water-soluble drugs. This positively charged SEDDS gives several fold increase in the bioavailability than the negatively charged one. The present study was undertaken to formulate and evaluate a positively charged SEDDS containing Ibuprofen. Fifteen formulations were prepared and optimized for the concentration of surfactants, cationic lipid oleylamine, oil component and the formulation variables like speed and extent of stirring. The prepared formulations were characterized for emulsion type, drug content, zeta potential and in-vitro. In-vitro absorption profile of positively charged SEDDS was compared with that of negatively charged SEDDS and pure drug. The formulations were analysed by FT-IR and subjected for stability studies. The optimized formulation consists of 2% oleylamine, 30% surfactants (tween 80 and span 80 in 3:1 ratio) and 68% oil component. Zeta potentials of the formulations were found to be positive and this positively charged SEDDS showed better absorption profile than the negatively charged SEDDS. FT-IR results showed that the Ibuprofen was compatible with the excipients and the stability studies revealed that the formulation has enough shelf life.
Authors and Affiliations
Parthasarathi Kulkarni, Mudit Dixit , R. Prudhvi , D. Lavanya , Vamsi Krishna Naga
Keywords
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