FORMULATION AND EVALUATION OF PRAVASTATIN SODIUM IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The aim of present investigation is to develop immediate release formulation of Pravastatin sodium for oral drug delivery by using suitable concentration of superdisintegrants. Croscarmellose sodium (AC-DI-SOL), povidone, MCC, Magnesium oxide, magnesium stearate were used to formulate the Immediate release tablet. Croscarmellose sodium was used as superdisintegrant and povidone was used as a binder to control the release of drug. Optimization of superdisintegrant concentration that can control the release of the drug as like the hypothetical release profile was based on release profile of the prepared trials. The Optimized batch F10 was showed good tablet properties like hardness (85-100N), thickness (5.2mm), friability (NIL) and nearly similar drug release profile to the hypothetical drug release profile of the innovator product. The optimized batch was also kept for accelerated stability study which showed no change in either physical appearance, drug content & drug release profile after storage at 40oC/75% RH for 2 months. It is concluded from the present investigation that Pravastatin sodium Immediate release tablet can be successfully formulated using combination of 15 mg (3.75%) Croscarmellose sodium and 8 mg (2%) Povidone. The Optimized formulation display better immediate release in 30 minutes.
Authors and Affiliations
Pinate Devanand , Ravikumar , Mahesh Kumar , A Senthil , Rahul Raut , V B Narayanaswamy
Keywords
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