Formulation and Evaluation of Ritonavir Solid Dispersions
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 2
Abstract
Ritonavir is an antiretroviral agent used in the treatment of AIDS having lowest water solubility of about 0.01mg/ml, indicates class IV drug bio-pharmaceutical classification systems, make an objective to study the solubility and dissolution by solid dispersion technique. Ritonavir solid dispersions are prepared using maltodextrin and poloxamer by solvent evaporation and kneading method at 1:1 and 1:3 drug: carrier and were evaluated for drug content, solubility, saturation solubility, FTIR, XRD, DSC and in-vitro dissolution.
Authors and Affiliations
P. Swathi| Department of Pharmaceutics, V.L. College of Pharmacy, Manik Prabhu Temple Road, Raichur - 584103, India, Y. Anand Kumar| Department of Pharmaceutics, V.L. College of Pharmacy, Manik Prabhu Temple Road, Raichur - 584103, India
Keywords
Related Articles
- EP ID EP16006
- DOI -
- Views 381
- Downloads 18
Evaluation of Preliminary Phytochemical and Pharmacognostic Studies on the Bark of Randia spinosa Thund
The bark of Randia spinosa (Madanphal) is reported to have great medicinal value. Pharmacognostic evaluation including examinations of morphological and microscopic characters, ash value, powder analysis, and extractive...
ASSOCIATION OF THE SHANK3 GENE COUPLED WITH 22Q13.3 DELETION SYNDROME
Phelan-McDermid syndrome (PMS) is a postnatal neurodegenerative disorder which is caused by the mutation in the gene called SHANK3, a member of the highly conserved Shank/ProSAP family of synaptic scaffolding proteins....
FUNCTIONALITY ADVANCEMENT OF POORLY SOLUBLE BIOVARIABLE ANTI HYPERTENSIVE DRUG BY SOPHISTICATED SD-FBP TECHNOLOGY AS PER ENHANCED QbD
Lacidipine (LCDP) is a dihydropyridine derivative categorized as an Anti-hypertensive Ca+2 channel blocker belonging to BCS class IV drug with low solubility and low permeability which presents a challenge to the formul...
Study to assess high demand and high commercial value Medicinal Plants of Jammu and Kashmir India - with special focus on routes of procurement and identification
Despite ancient nature of the tradition, medicinal plants still form the basis of traditional or indigenous health systems and are reported by the World Health Organization (WHO) to still be used by the majority of the...
Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.)
The most common disease nowadays is diabetes. In a fast-changing world, many means to treat diabetes naturally are explored by experts and clinicians today. Continuing use of insulin and other oral hypoglycemic agent c...