FORMULATION AND EVALUATION OF SELF PORE FORMING OSMOTIC TABLETS OF GLIPIZIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The purpose of this study was to formulate and evaluate self pore forming osmotically controlled drug delivery system of Glipizide. Glipizide is an oral hypoglycemic agent which belongs to BCS class II with relatively short elimination half life of 2-4 hours. Main objective to formulate this system was to achieve zero order release for Glipizide. The present study was also aimed to develop a system that would reduce the frequency of dosing and thus increases patient compliance. Cellulose acetate was used as a film forming polymer. PEG 400 was used as plasticizer. Potassium chloride was used as pore forming agent. Acetone and methanol were used as solvent. Combinations of Mannitol-Fructose, Mannitol-Sucrose and Lactose-Sucrose were used as osmotic agents. This system was developed in two stages: (a) formulation of core tablet and (b) coating of tablet core. Core tablets were evaluated for content uniformity, hardness and weight variation while coated tablets were evaluated for film thickness and in vitro release study. Effect of varying the concentration of pore forming agent on release rate was studied. Effect of various osmogens differing in osmotic pressure on release rate was also evaluated.
Authors and Affiliations
Dhruv Mangukia , Sangeeta Asija , Chirag Patel , Jaimin Patel , Ishita Sojitra
Keywords
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