FORMULATION AND EVALUATION OF SOLID-SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) FOR GLIBENCLAMIDE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 1
Abstract
Glibenclamide (GBD) is one of the most prescribed long-acting anti hyperglycaemic agent used in the treatment of treat Type 2 diabetes mellitus. GBD is a poorly soluble drug which results in low bioavailability. Hence, the objective of the study is to develop a solid self-nano emulsifying drug delivery system (S-SNEDDS) to improve the solubility and dissolution rate of GBD. Liquid SNEDDS was prepared using Maisine-35-1 as oil, Cremophor RH40 as surfactant, and PEG 400 as cosurfactant. Ternary phase diagrams were constructed to identify the self-nano emulsification region. Based on the phase diagrams, few formulations containing 10-25% of oil were prepared by simple mixing and vortexing. These formulations were adsorbed onto Neusilin US2 to produce solid SNEDDS and were evaluated for drug content, globule size, zeta potential and in vitro drug release. DSC and FTIR studies were also performed and the results indicated that there were no incompatibilities between GBD and the components in the SNEDDS. The prepared formulations exhibited a globule size ranging from 14.14 to 45.36 nm. In vitro dissolution profiles showed that dissolution rate of Glibenclamide from liquid and solid SNEDDS was much greater when compared to the pure drug and the marketed tablet. Thus, this study indicated that the solid SNEDDS could be used as a potential drug carrier for GBD with improved solubility and dissolution rate.
Authors and Affiliations
Sreenivas Patro Sisinthy
Keywords
Related Articles
- EP ID EP666946
- DOI -
- Views 144
- Downloads 0
SYNTHESIS AND CHARACTERIZATION OF DILTIAZEM LOADED EUDRAGIT RS 100 “MICROSPONGES”
In this study, we report successful synthesis of porous polymeric microspheres with “microsponge” type morphology by quasi-emulsion solvent diffusion method. Over the past few years the “Microsponge Delivery Systems - MD...
ANTIBACTERIAL & ANTIFUNGAL POTENTIALITY OF RICINUS COMMUNIS & COLEUS FORSKOHLII ON SOME HUMAN PATHOGENIC MICROORGANISMS
The objective of the present study was to explore the antibacterial and antifungal activity of two plant extracts (Ricinus communis & Coleus forskohlii) against some selected pathogen (Staphylococcus aureus, Escherichia...
SIGNIFICANCE OF ALPHA FETO-PROTEIN AND OTHER BIOCHEMICAL MARKERS IN THALASSEMIA ADULT PATIENTS
Thalassemia is blood disease represented by decreased or absent in the formation of globulin chains. In this case adult patients suffering from anemia, iron overload and blood transfusion, the complication of thalassemia...
PHYTOCHEMICAL ANALYSIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY DETERMINATION OF MOMORDICA CHARANTIA
Momordica charantia is commonly known as bitter melon or bitter gourd, with Ayurveda name: karela.[1] It is found in the tropical and subtropical regions of the world, distributed in Asian countries and widely cultivated...
DIVERSION FROM ADULTS ANTIBIOTIC CLINICAL GUIDELINES: A STUDY AT THE MEDICAL DEPARTMENT; AL HADA MILITARY HOSPITAL, TAIF, KSA.
Background: Antibiotic clinical guidelines ensure the appropriateness of treatment, improve quality of care, reduce the level of resistant organisms and finally promote evidence –based decision making. Objectives: To mea...