FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM USING MODIFIED CASHEW GUM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The objective of this study was to formulate and evaluate sustained release tablets using cashew gum and cross-linked cashew gum as controlled release polymer.Methods: Full factorial design of 23 was employed to optimize the formulation. Cashew gum (CG), cross-linked cashew gum (CCG) and microcrystalline cellulose (MCC) were selected as independent variables. The dependent variables selected were % of drug released in 1st h (Y1), % of drug released at 12th h (Y2), and diffusion exponent n (Y3). Tablets were prepared by direct compression and powder properties were evaluated indicating fairly good flow properties. Prepared tablets were evaluated for weight variation, hardness, friability, drug content and for dissolution profile. The optimized formulation obtained from the factorial design was subjected to in vivo studies.Results: In vitro dissolution, swelling and erosion studies were carried out for 12 h in the specified buffer solution. Kinetic analysis of dissolution data showed a good fit in Peppas equation confirming both diffusion and erosion had controlled the drug release. In vivo studies for the marketed and optimized formulation showed that there was no significant difference between the two, confirming the sustained release profile. The stability study for optimized formulation showed better results.Conclusion: The research findings obtained from the studies were found to be satisfactory. It can be concluded that natural gums and their derivatives can be effectively used for preparation of sustained release tablets. The results have shown an indication of the usage of natural gums as an effective alternative to synthetic polymers.
Authors and Affiliations
Rohit R. Bhosale, Riyaz Ali M. Osmani, Padmaja C, Afrasim Moin
Keywords
Related Articles
- EP ID EP578860
- DOI -
- Views 47
- Downloads 0
A PROSPECTIVE COMPARATIVE OBSERVATIONAL STUDY ON SAFETY, EFFICACY AND COST EFFECTIVENESS OF INSULIN AND THEIR ANALOGUES
Objective: The objective of this study was to compare safety, efficacy and cost effectiveness of insulin and their analogues when compared with human insulin in patients with type-2 diabetes mellitus.Methods: A prospec...
BIOPROCESS MODELING FOR THE PREDICTION OF THERAPEUTIC ENZYME L-ASPARAGINASE ACTIVITY IN SOLID STATE FERMENTATION USING MULTIPLE LINEAR REGRESSION AND ANN
Objective: L-asparaginase is an enzyme of industrial as well as therapeutic importance. The capabilities of bioprocess modeling of L-Asparaginase activity produced from Aspergillus niger by solid state fermentation (SSF)...
THE CORRELATION BETWEEN FRAMINGHAM RISK SCORE AND THE CLINICAL AND BIOCHEMICAL PARAMETERS THAT MEASURE FUNCTIONAL DISABILITY AND DISEASE ACTIVITY IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS
Objective: Rheumatoid arthritis (RA) patients have increased morbidity and mortality from premature cardiovascular (CV) disease (CVD). Framingham risk score (FRS) is a simplified coronary prediction tool developed to ena...
DEVELOPMENT AND VALIDATION OF CARBAMAZEPINE PLASMA CONCENTRATIONS MEASUREMENT AND ITS APPLICATION ON EPILEPSY PATIENTS
Objective: To develop and validate high-performance liquid chromatography with photodiode array (HPLC-PDA) detector as a method for measuring carbamazepine plasma concentrations in epilepsy patients treated with monother...
DECOLOURIZATION OF TRIPHENYLMETHANE DYES AND DYE INDUSTRY EFFLUENT BY STAPHYLOCOCCUS AUREUS ISOLATED FROM DYE CONTAMINATED SITE
Objective: The objectives of the present study were a) to isolate and screen bacteria for dye removal from synthetic solution b) to optimize various variables such as pH, static/shaking and initial dye concentration on d...