FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM USING MODIFIED CASHEW GUM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The objective of this study was to formulate and evaluate sustained release tablets using cashew gum and cross-linked cashew gum as controlled release polymer.Methods: Full factorial design of 23 was employed to optimize the formulation. Cashew gum (CG), cross-linked cashew gum (CCG) and microcrystalline cellulose (MCC) were selected as independent variables. The dependent variables selected were % of drug released in 1st h (Y1), % of drug released at 12th h (Y2), and diffusion exponent n (Y3). Tablets were prepared by direct compression and powder properties were evaluated indicating fairly good flow properties. Prepared tablets were evaluated for weight variation, hardness, friability, drug content and for dissolution profile. The optimized formulation obtained from the factorial design was subjected to in vivo studies.Results: In vitro dissolution, swelling and erosion studies were carried out for 12 h in the specified buffer solution. Kinetic analysis of dissolution data showed a good fit in Peppas equation confirming both diffusion and erosion had controlled the drug release. In vivo studies for the marketed and optimized formulation showed that there was no significant difference between the two, confirming the sustained release profile. The stability study for optimized formulation showed better results.Conclusion: The research findings obtained from the studies were found to be satisfactory. It can be concluded that natural gums and their derivatives can be effectively used for preparation of sustained release tablets. The results have shown an indication of the usage of natural gums as an effective alternative to synthetic polymers.
Authors and Affiliations
Rohit R. Bhosale, Riyaz Ali M. Osmani, Padmaja C, Afrasim Moin
Keywords
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